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Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART.

Publication ,  Journal Article
Mansour, M; Radaideh, Q; Alaiwah, MN; Alnimer, Y; Devabhaktuni, SR; Dhar, G; Vallurupalli, S; Michos, ED; Newby, DE; Williams, MC; Fudim, M ...
Published in: Int J Cardiovasc Imaging
March 2022

The presence of non-obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA) has been associated with the occurrence of major adverse cardiac events (MACE). However, factors associated with the development of MACE in symptomatic women with non-obstructive CAD on coronary CTA have not been fully elucidated. We sought to examine the influence of risk factors and coronary artery calcification on MACE in symptomatic women with non-obstructive CAD on coronary CTA. Women from PROMISE and SCOT-HEART trials with none or non-obstructive CAD on coronary CTA comprised the study cohort. Baseline characteristics and clinical presentation were assessed. Survival analysis using Kaplan-Meier curves was done to compare outcomes stratified by the atherosclerotic cardiovascular disease (ASCVD) risk score and the Agatston score. The primary endpoint was a composite of all-cause mortality, myocardial infarction, and revascularization. 2597 women had non-obstructive CAD or normal coronary CTA, with a median follow-up of 32 months. Compared to women without MACE, women with MACE had lower high-density lipoprotein cholesterol (HDL-C) levels and higher mean ASCVD risk scores. Further, women with non-obstructive CAD and ASCVD ≥ 7.5% had higher risk of MACE than those with ASCVD < 7.5% [3.2% vs. 1.1%, adjusted HR (aHR) of 3.1 (95% CI 1.32, 7.23), P-value 0.009]. The Agatston calcium score, on the other hand, was not independently associated with MACE among this population of symptomatic women. Symptomatic women with non-obstructive CAD on coronary CTA are at higher risk for MACE, with the ASCVD risk score being independently associated with the occurrence of adverse events.

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Published In

Int J Cardiovasc Imaging

DOI

EISSN

1875-8312

Publication Date

March 2022

Volume

38

Issue

3

Start / End Page

683 / 693

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Coronary Artery Disease
  • Coronary Angiography
  • Computed Tomography Angiography
 

Citation

APA
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Mansour, M., Radaideh, Q., Alaiwah, M. N., Alnimer, Y., Devabhaktuni, S. R., Dhar, G., … Al’Aref, S. J. (2022). Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART. Int J Cardiovasc Imaging, 38(3), 683–693. https://doi.org/10.1007/s10554-021-02429-3
Mansour, Munthir, Qais Radaideh, Malek N. Alaiwah, Yanal Alnimer, Subodh R. Devabhaktuni, Gaurav Dhar, Srikanth Vallurupalli, et al. “Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART.Int J Cardiovasc Imaging 38, no. 3 (March 2022): 683–93. https://doi.org/10.1007/s10554-021-02429-3.
Mansour M, Radaideh Q, Alaiwah MN, Alnimer Y, Devabhaktuni SR, Dhar G, et al. Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART. Int J Cardiovasc Imaging. 2022 Mar;38(3):683–93.
Mansour, Munthir, et al. “Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART.Int J Cardiovasc Imaging, vol. 38, no. 3, Mar. 2022, pp. 683–93. Pubmed, doi:10.1007/s10554-021-02429-3.
Mansour M, Radaideh Q, Alaiwah MN, Alnimer Y, Devabhaktuni SR, Dhar G, Vallurupalli S, Michos ED, Newby DE, Williams MC, Fudim M, Al’Aref SJ. Major adverse cardiac events in symptomatic women with non-obstructive CAD on coronary CTA: pooled analysis from PROMISE and SCOT-HEART. Int J Cardiovasc Imaging. 2022 Mar;38(3):683–693.

Published In

Int J Cardiovasc Imaging

DOI

EISSN

1875-8312

Publication Date

March 2022

Volume

38

Issue

3

Start / End Page

683 / 693

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Coronary Artery Disease
  • Coronary Angiography
  • Computed Tomography Angiography