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Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.

Publication ,  Journal Article
Miles, AE; Dos Santos, FC; Byrne, EM; Renteria, ME; McIntosh, AM; Adams, MJ; Pistis, G; Castelao, E; Preisig, M; Baune, BT; Schubert, KO ...
Published in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
December 2021

Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational gap, we recently developed a transcriptome-based polygenic risk score (T-PRS) based on common functional variants capturing 'depression-like' shifts in cortical gene expression. Here, we used a non-clinical sample of young adults (n = 482, Duke Neurogenetics Study: 53% women; aged 19.8 ± 1.2 years) to map T-PRS onto brain morphology measures, including Freesurfer-derived subcortical volume, cortical thickness, surface area, and local gyrification index, as well as broad MDD risk, indexed by self-reported family history of depression. We conducted side-by-side comparisons with a PRS independently derived from a Psychiatric Genomics Consortium (PGC) MDD GWAS (PGC-PRS), and sought to link T-PRS with diagnosis and symptom severity directly in PGC-MDD participants (n = 29,340, 59% women; 12,923 MDD cases, 16,417 controls). T-PRS was associated with smaller amygdala volume in women (t = -3.478, p = 0.001) and lower prefrontal gyrification across sexes. In men, T-PRS was associated with hypergyrification in temporal and occipital regions. Prefrontal hypogyrification mediated a male-specific indirect link between T-PRS and familial depression (b = 0.005, p = 0.029). PGC-PRS was similarly associated with lower amygdala volume and cortical gyrification; however, both effects were male-specific and hypogyrification emerged in distinct parietal and temporo-occipital regions, unassociated with familial depression. In PGC-MDD, T-PRS did not predict diagnosis (OR = 1.007, 95% CI = [0.997-1.018]) but correlated with symptom severity in men (rho = 0.175, p = 7.957 × 10-4) in one cohort (N = 762, 48% men). Depression-like shifts in cortical gene expression have sex-specific effects on brain morphology and may contribute to broad depression vulnerability in men.

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Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

December 2021

Volume

46

Issue

13

Start / End Page

2304 / 2311

Related Subject Headings

  • Young Adult
  • Transcriptome
  • Psychiatry
  • Multifactorial Inheritance
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Depressive Disorder, Major
  • Depression
 

Citation

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Chicago
ICMJE
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Miles, A. E., Dos Santos, F. C., Byrne, E. M., Renteria, M. E., McIntosh, A. M., Adams, M. J., … Nikolova, Y. S. (2021). Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 46(13), 2304–2311. https://doi.org/10.1038/s41386-021-01189-x
Miles, Amy E., Fernanda C. Dos Santos, Enda M. Byrne, Miguel E. Renteria, Andrew M. McIntosh, Mark J. Adams, Giorgio Pistis, et al. “Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 46, no. 13 (December 2021): 2304–11. https://doi.org/10.1038/s41386-021-01189-x.
Miles AE, Dos Santos FC, Byrne EM, Renteria ME, McIntosh AM, Adams MJ, et al. Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 Dec;46(13):2304–11.
Miles, Amy E., et al. “Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 46, no. 13, Dec. 2021, pp. 2304–11. Epmc, doi:10.1038/s41386-021-01189-x.
Miles AE, Dos Santos FC, Byrne EM, Renteria ME, McIntosh AM, Adams MJ, Pistis G, Castelao E, Preisig M, Baune BT, Schubert KO, Lewis CM, Jones LA, Jones I, Uher R, Smoller JW, Perlis RH, Levinson DF, Potash JB, Weissman MM, Shi J, Lewis G, Penninx BWJH, Boomsma DI, Hamilton SP, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sibille E, Hariri AR, Nikolova YS. Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 Dec;46(13):2304–2311.

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

December 2021

Volume

46

Issue

13

Start / End Page

2304 / 2311

Related Subject Headings

  • Young Adult
  • Transcriptome
  • Psychiatry
  • Multifactorial Inheritance
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Depressive Disorder, Major
  • Depression