Molecular aspects of fructose metabolism and metabolic disease.
Excessive sugar consumption is increasingly considered as a contributor to the emerging epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet in the form of sucrose or high-fructose corn syrup, both of which comprise nearly equal amounts of glucose and fructose. The unique aspects of fructose metabolism and properties of fructose-derived metabolites allow for fructose to serve as a physiological signal of normal dietary sugar consumption. However, when fructose is consumed in excess, these unique properties may contribute to the pathogenesis of cardiometabolic disease. Here, we review the biochemistry, genetics, and physiology of fructose metabolism and consider mechanisms by which excessive fructose consumption may contribute to metabolic disease. Lastly, we consider new therapeutic options for the treatment of metabolic disease based upon this knowledge.
Duke Scholars
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Related Subject Headings
- Obesity
- Metabolic Diseases
- Liver
- Humans
- Glucose
- Fructose
- Endocrinology & Metabolism
- Diet
- 3205 Medical biochemistry and metabolomics
- 3101 Biochemistry and cell biology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Obesity
- Metabolic Diseases
- Liver
- Humans
- Glucose
- Fructose
- Endocrinology & Metabolism
- Diet
- 3205 Medical biochemistry and metabolomics
- 3101 Biochemistry and cell biology