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MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS

Immunotherapy in gastrointestinal malignancies

Publication ,  Chapter
Morse, MA
August 30, 2016

Recent reports of efficacy of immune therapies in solid tumors other than melanoma and renal cell carcinoma have raised enthusiasm for testing immunotherapy in gastrointestinal (GI) malignancies. Strategies under development include antibodies and related molecules that mediate cellular cytotoxicity, vaccines intended to activate tumor-specific T cell and antibody responses, adoptive transfer of natural killer (NK) cells, tumor infiltrating lymphocytes, and chimeric antigen receptor T cells, and immunomodulatory drugs such as checkpoint blocking antibodies. Thus far, benefit has been modest although insights from these studies have provided new directions for testing. We will review the current status of the various immunotherapy approaches undergoing testing in GI malignancies.

Duke Scholars

DOI

ISBN

9789814651875

Publication Date

August 30, 2016

Start / End Page

27 / 69
 

Citation

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Morse, M. A. (2016). Immunotherapy in gastrointestinal malignancies. In MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS (pp. 27–69). https://doi.org/10.1142/9789814651875_0002
Morse, M. A. “Immunotherapy in gastrointestinal malignancies.” In MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS, 27–69, 2016. https://doi.org/10.1142/9789814651875_0002.
Morse MA. Immunotherapy in gastrointestinal malignancies. In: MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS. 2016. p. 27–69.
Morse, M. A. “Immunotherapy in gastrointestinal malignancies.” MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS, 2016, pp. 27–69. Scopus, doi:10.1142/9789814651875_0002.
Morse MA. Immunotherapy in gastrointestinal malignancies. MULTIDISCIPLINARY MANAGEMENT OF GASTROINTESTINAL CANCERS. 2016. p. 27–69.
Journal cover image

DOI

ISBN

9789814651875

Publication Date

August 30, 2016

Start / End Page

27 / 69