Skip to main content

Molecular pathways and therapeutic targets in lung cancer.

Publication ,  Journal Article
Shtivelman, E; Hensing, T; Simon, GR; Dennis, PA; Otterson, GA; Bueno, R; Salgia, R
Published in: Oncotarget
March 30, 2014

Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emphasis on the clinical implications of the increasing number of actionable molecular targets. It describes the major pathways and molecular alterations implicated in the development and progression of non-small cell lung cancer (adenocarcinoma and squamous cancer), and of small cell carcinoma, emphasizing the molecular alterations comprising the specific blueprints in each group. The approved and investigational targeted therapies as well as the immune therapies, and clinical trials exploring the variety of targeted approaches to treatment of lung cancer are the main focus of this review.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 30, 2014

Volume

5

Issue

6

Start / End Page

1392 / 1433

Location

United States

Related Subject Headings

  • Signal Transduction
  • Neoplasms
  • Neoplasm Proteins
  • Molecular Targeted Therapy
  • Humans
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shtivelman, E., Hensing, T., Simon, G. R., Dennis, P. A., Otterson, G. A., Bueno, R., & Salgia, R. (2014). Molecular pathways and therapeutic targets in lung cancer. Oncotarget, 5(6), 1392–1433. https://doi.org/10.18632/oncotarget.1891
Shtivelman, Emma, Thomas Hensing, George R. Simon, Phillip A. Dennis, Gregory A. Otterson, Raphael Bueno, and Ravi Salgia. “Molecular pathways and therapeutic targets in lung cancer.Oncotarget 5, no. 6 (March 30, 2014): 1392–1433. https://doi.org/10.18632/oncotarget.1891.
Shtivelman E, Hensing T, Simon GR, Dennis PA, Otterson GA, Bueno R, et al. Molecular pathways and therapeutic targets in lung cancer. Oncotarget. 2014 Mar 30;5(6):1392–433.
Shtivelman, Emma, et al. “Molecular pathways and therapeutic targets in lung cancer.Oncotarget, vol. 5, no. 6, Mar. 2014, pp. 1392–433. Pubmed, doi:10.18632/oncotarget.1891.
Shtivelman E, Hensing T, Simon GR, Dennis PA, Otterson GA, Bueno R, Salgia R. Molecular pathways and therapeutic targets in lung cancer. Oncotarget. 2014 Mar 30;5(6):1392–1433.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 30, 2014

Volume

5

Issue

6

Start / End Page

1392 / 1433

Location

United States

Related Subject Headings

  • Signal Transduction
  • Neoplasms
  • Neoplasm Proteins
  • Molecular Targeted Therapy
  • Humans
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis