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Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.

Publication ,  Journal Article
Turley, MC; Moore, C; Creasy, JM; Sharib, J; Lan, B; Thacker, JKM; Migaly, J; Zani, S; Allen, PJ; Mantyh, CR; Lidsky, ME
Published in: J Gastrointest Surg
April 2022

BACKGROUND: Colorectal liver metastases (CRLM) are the most common cause of disease-specific mortality in patients with colorectal cancer. Hepatic artery infusion (HAI) combined with systemic chemotherapy improves survival for these patients. The safety of colorectal resection at the time of HAI pump placement has not been well established. METHODS: Patients with CRLM who underwent combined HAI pump placement and colorectal (primary) resection or HAI pump placement alone were evaluated for perioperative outcomes, pump-specific complications, infectious complications, and time to treatment initiation. These outcomes were compared using comparative statistics. RESULTS: Patients who underwent combined HAI pump placement and primary resection (n = 19) vs HAI pump placement alone (n = 13) had similar demographics and rates of combined hepatectomy. Combined HAI pump placement and primary resection group had similar operative time and blood loss (both p = NS), but longer length of stay (6 vs 4 days, p = 0.02) compared to pump placement alone. Overall postoperative complications (21% vs 8%) and pump-specific complications (16% vs 31%) were similar (both p = NS). Infection rates were not different between groups, nor was time to initiation of HAI therapy (19 vs 16 days p = NS), or systemic therapy (34 vs 35 days p = NS). CONCLUSION: Combining colorectal resection with HAI pump implantation is a safe surgical approach for management of unresectable CRLM. Postoperative complications, specifically infectious complications, were not increased, nor was there a delay to initiation of HAI or systemic chemotherapy. Investigation of long-term oncologic outcomes for HAI pump placement and primary tumor resection in patients with unresectable CRLM is ongoing.

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Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

April 2022

Volume

26

Issue

4

Start / End Page

764 / 771

Location

Netherlands

Related Subject Headings

  • Surgery
  • Postoperative Complications
  • Liver Neoplasms
  • Infusions, Intra-Arterial
  • Infusion Pumps
  • Humans
  • Hepatic Artery
  • Fluorouracil
  • Colorectal Neoplasms
  • Antineoplastic Combined Chemotherapy Protocols
 

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Turley, M. C., Moore, C., Creasy, J. M., Sharib, J., Lan, B., Thacker, J. K. M., … Lidsky, M. E. (2022). Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases. J Gastrointest Surg, 26(4), 764–771. https://doi.org/10.1007/s11605-021-05195-8
Turley, Megan C., Carrie Moore, John M. Creasy, Jeremy Sharib, Billy Lan, Julie K. M. Thacker, John Migaly, et al. “Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.J Gastrointest Surg 26, no. 4 (April 2022): 764–71. https://doi.org/10.1007/s11605-021-05195-8.
Turley MC, Moore C, Creasy JM, Sharib J, Lan B, Thacker JKM, et al. Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases. J Gastrointest Surg. 2022 Apr;26(4):764–71.
Turley, Megan C., et al. “Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.J Gastrointest Surg, vol. 26, no. 4, Apr. 2022, pp. 764–71. Pubmed, doi:10.1007/s11605-021-05195-8.
Turley MC, Moore C, Creasy JM, Sharib J, Lan B, Thacker JKM, Migaly J, Zani S, Allen PJ, Mantyh CR, Lidsky ME. Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases. J Gastrointest Surg. 2022 Apr;26(4):764–771.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

April 2022

Volume

26

Issue

4

Start / End Page

764 / 771

Location

Netherlands

Related Subject Headings

  • Surgery
  • Postoperative Complications
  • Liver Neoplasms
  • Infusions, Intra-Arterial
  • Infusion Pumps
  • Humans
  • Hepatic Artery
  • Fluorouracil
  • Colorectal Neoplasms
  • Antineoplastic Combined Chemotherapy Protocols