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Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes.

Publication ,  Journal Article
Wang, Y; Xu, C; Park, J-H; Lee, S; Stern, Y; Yoo, S; Kim, JH; Kim, HS; Cha, J; Alzheimer's Disease Neuroimaging Initiative,
Published in: Neuroimage Clin
2019

Accurate, reliable prediction of risk for Alzheimer's disease (AD) is essential for early, disease-modifying therapeutics. Multimodal MRI, such as structural and diffusion MRI, is likely to contain complementary information of neurodegenerative processes in AD. Here we tested the utility of the multimodal MRI (T1-weighted structure and diffusion MRI), combined with high-throughput brain phenotyping-morphometry and structural connectomics-and machine learning, as a diagnostic tool for AD. We used, firstly, a clinical cohort at a dementia clinic (National Health Insurance Service-Ilsan Hospital [NHIS-IH]; N = 211; 110 AD, 64 mild cognitive impairment [MCI], and 37 cognitively normal with subjective memory complaints [SMC]) to test the diagnostic models; and, secondly, Alzheimer's Disease Neuroimaging Initiative (ADNI)-2 to test the generalizability. Our machine learning models trained on the morphometric and connectome estimates (number of features = 34,646) showed optimal classification accuracy (AD/SMC: 97% accuracy, MCI/SMC: 83% accuracy; AD/MCI: 97% accuracy) in NHIS-IH cohort, outperforming a benchmark model (FLAIR-based white matter hyperintensity volumes). In ADNI-2 data, the combined connectome and morphometry model showed similar or superior accuracies (AD/HC: 96%; MCI/HC: 70%; AD/MCI: 75% accuracy) compared with the CSF biomarker model (t-tau, p-tau, and Amyloid β, and ratios). In predicting MCI to AD progression in a smaller cohort of ADNI-2 (n = 60), the morphometry model showed similar performance with 69% accuracy compared with CSF biomarker model with 70% accuracy. Our comparisons of the classifiers trained on structural MRI, diffusion MRI, FLAIR, and CSF biomarkers showed the promising utility of the white matter structural connectomes in classifying AD and MCI in addition to the widely used structural MRI-based morphometry, when combined with machine learning.

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Published In

Neuroimage Clin

DOI

EISSN

2213-1582

Publication Date

2019

Volume

23

Start / End Page

101859

Location

Netherlands

Related Subject Headings

  • White Matter
  • Prognosis
  • Neuroimaging
  • Multimodal Imaging
  • Male
  • Magnetic Resonance Imaging
  • Machine Learning
  • Humans
  • Female
  • Diffusion Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, Y., Xu, C., Park, J.-H., Lee, S., Stern, Y., Yoo, S., … Alzheimer’s Disease Neuroimaging Initiative, . (2019). Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes. Neuroimage Clin, 23, 101859. https://doi.org/10.1016/j.nicl.2019.101859
Wang, Yun, Chenxiao Xu, Ji-Hwan Park, Seonjoo Lee, Yaakov Stern, Shinjae Yoo, Jong Hun Kim, Hyoung Seop Kim, Jiook Cha, and Jiook Alzheimer’s Disease Neuroimaging Initiative. “Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes.Neuroimage Clin 23 (2019): 101859. https://doi.org/10.1016/j.nicl.2019.101859.
Wang Y, Xu C, Park J-H, Lee S, Stern Y, Yoo S, et al. Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes. Neuroimage Clin. 2019;23:101859.
Wang, Yun, et al. “Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes.Neuroimage Clin, vol. 23, 2019, p. 101859. Pubmed, doi:10.1016/j.nicl.2019.101859.
Wang Y, Xu C, Park J-H, Lee S, Stern Y, Yoo S, Kim JH, Kim HS, Cha J, Alzheimer’s Disease Neuroimaging Initiative. Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes. Neuroimage Clin. 2019;23:101859.
Journal cover image

Published In

Neuroimage Clin

DOI

EISSN

2213-1582

Publication Date

2019

Volume

23

Start / End Page

101859

Location

Netherlands

Related Subject Headings

  • White Matter
  • Prognosis
  • Neuroimaging
  • Multimodal Imaging
  • Male
  • Magnetic Resonance Imaging
  • Machine Learning
  • Humans
  • Female
  • Diffusion Magnetic Resonance Imaging