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Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review.

Publication ,  Journal Article
Wei, S; Le, N; Zhu, JW; Breathett, K; Greene, SJ; Mamas, MA; Zannad, F; Van Spall, HGC
Published in: Circ Heart Fail
March 2022

BACKGROUND: Heart failure has a disproportionate burden on patients who are Black, Indigenous, and people of color (BIPOC), but not much is known about representation of these groups in randomized controlled trials (RCTs). We explored temporal trends in and RCT factors associated with the reporting of race and ethnicity data and the enrollment of BIPOC in heart failure RCTs. METHODS: We searched MEDLINE, EMBASE, and CINAHL for heart failure RCTs published in journals with an impact factor ≥10 between January 1, 2000 and June 17, 2020. We used the Cochran-Armitage and Jonchkeere-Terpstra tests to examine temporal trends, and multivariable regression to assess the association between trial characteristics and outcomes. RESULTS: Of 414 RCTs meeting inclusion criteria, only 157 (37.9% [95% CI, 33.2%-2.8%]) reported race and ethnicity data. Among 158 200 participants in these 157 RCTs, 29 512 (18.7% [95% CI, 18.5%-18.9%]) were BIPOC. There was a temporal increase in reporting of race and ethnicity data (29.5% in 2000-2003 to 54.7% in 2016-2020, P<0.001) and in enrollment of BIPOC (14.4% in 2000-2003 to 22.2% in 2016-2020, P=0.038). Trial leadership by a woman was independently associated with twice the odds of reporting race and ethnicity data (odds ratio, 2.0 [95% CI, 1.1-3.8]; P=0.028) and an 8.4% increase (95% CI, 1.9%-15.0%; P=0.013) in BIPOC enrollment. CONCLUSIONS: A minority of heart failure RCTs reported race and ethnicity data, and among these, BIPOC were under-enrolled relative to disease distribution. Both reporting of race and ethnicity as well as enrollment of BIPOC increased between 2000 and 2020. After multivariable adjustment, trials led by women had greater odds of reporting race and ethnicity and enrolling BIPOC. REGISTRATION: URL: https://www.crd.york.ac.uk/PROSPERO/; Unique identifier: CRD42021237497.

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Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

March 2022

Volume

15

Issue

3

Start / End Page

e008685

Location

United States

Related Subject Headings

  • Humans
  • Heart Failure
  • Female
  • Ethnicity
  • Cardiovascular System & Hematology
  • Bibliometrics
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Wei, S., Le, N., Zhu, J. W., Breathett, K., Greene, S. J., Mamas, M. A., … Van Spall, H. G. C. (2022). Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circ Heart Fail, 15(3), e008685. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685
Wei, Sunny, NhatChinh Le, Jie Wei Zhu, Khadijah Breathett, Stephen J. Greene, Mamas A. Mamas, Faiez Zannad, and Harriette G. C. Van Spall. “Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review.Circ Heart Fail 15, no. 3 (March 2022): e008685. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008685.
Wei S, Le N, Zhu JW, Breathett K, Greene SJ, Mamas MA, et al. Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circ Heart Fail. 2022 Mar;15(3):e008685.
Wei, Sunny, et al. “Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review.Circ Heart Fail, vol. 15, no. 3, Mar. 2022, p. e008685. Pubmed, doi:10.1161/CIRCHEARTFAILURE.121.008685.
Wei S, Le N, Zhu JW, Breathett K, Greene SJ, Mamas MA, Zannad F, Van Spall HGC. Factors Associated With Racial and Ethnic Diversity Among Heart Failure Trial Participants: A Systematic Bibliometric Review. Circ Heart Fail. 2022 Mar;15(3):e008685.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

March 2022

Volume

15

Issue

3

Start / End Page

e008685

Location

United States

Related Subject Headings

  • Humans
  • Heart Failure
  • Female
  • Ethnicity
  • Cardiovascular System & Hematology
  • Bibliometrics
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 1102 Cardiorespiratory Medicine and Haematology