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Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.

Publication ,  Journal Article
Zayed, Y; Barbarawi, M; Kheiri, B; Banifadel, M; Haykal, T; Chahine, A; Rashdan, L; Aburahma, A; Bachuwa, G; Seedahmed, E
Published in: Journal of critical care
April 2019

Delirium commonly presents as a complication in critically ill patients. Our aim is to perform a meta-analysis investigating the role of haloperidol versus placebo in management (treatment and prophylaxis), of delirium in intensive care unit (ICU).Our study is a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing haloperidol versus placebo for treatment and/or prophylaxis of ICU-related delirium.Six RCTs representing 2552 patients. There was no significant difference between haloperidol and placebo-treated patients in short-term all-cause mortality (risk ratio [RR] 0.96; 95% confidence interval [CI] 0.81-1.14; P = 0.67), incidence of delirium (RR 0.93; 95% CI 0.65-1.34; P = 0.70), ICU length of stay (Mean difference [MD] 0.00 days; 95% CI -0.82-0.83; P = 0.99), or delirium/coma-free days (MD 0.09; 95% CI -0.05-0.24; P = 0.21). Haloperidol was not associated with increased risk for serious adverse events (RR 0.65; 95% CI 0.23-1.88; P = 0.43), QTc prolongation (RR 0.87; 95% CI 0.63-1.19; P = 0.38), or extrapyramidal symptoms (RR 0.84; 95% CI 0.57-1.23; P = 0.37).Among critically ill patients, haloperidol administration compared with placebo does not significantly affect short-term mortality, incidence of delirium, ICU length of stay, or delirium or coma-free days. Additionally, there was no increased risk of adverse events.

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Published In

Journal of critical care

DOI

EISSN

1557-8615

ISSN

0883-9441

Publication Date

April 2019

Volume

50

Start / End Page

280 / 286

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Intensive Care Units
  • Humans
  • Haloperidol
  • Emergency & Critical Care Medicine
  • Delirium
  • Critical Illness
  • Antipsychotic Agents
  • Adult
 

Citation

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ICMJE
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Zayed, Y., Barbarawi, M., Kheiri, B., Banifadel, M., Haykal, T., Chahine, A., … Seedahmed, E. (2019). Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. Journal of Critical Care, 50, 280–286. https://doi.org/10.1016/j.jcrc.2019.01.009
Zayed, Yazan, Mahmoud Barbarawi, Babikir Kheiri, Momen Banifadel, Tarek Haykal, Adam Chahine, Laith Rashdan, Ahmed Aburahma, Ghassan Bachuwa, and Elfateh Seedahmed. “Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.Journal of Critical Care 50 (April 2019): 280–86. https://doi.org/10.1016/j.jcrc.2019.01.009.
Zayed Y, Barbarawi M, Kheiri B, Banifadel M, Haykal T, Chahine A, et al. Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. Journal of critical care. 2019 Apr;50:280–6.
Zayed, Yazan, et al. “Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.Journal of Critical Care, vol. 50, Apr. 2019, pp. 280–86. Epmc, doi:10.1016/j.jcrc.2019.01.009.
Zayed Y, Barbarawi M, Kheiri B, Banifadel M, Haykal T, Chahine A, Rashdan L, Aburahma A, Bachuwa G, Seedahmed E. Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. Journal of critical care. 2019 Apr;50:280–286.
Journal cover image

Published In

Journal of critical care

DOI

EISSN

1557-8615

ISSN

0883-9441

Publication Date

April 2019

Volume

50

Start / End Page

280 / 286

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Intensive Care Units
  • Humans
  • Haloperidol
  • Emergency & Critical Care Medicine
  • Delirium
  • Critical Illness
  • Antipsychotic Agents
  • Adult