Catheter ablation of atrial fibrillation with heart failure: An updated meta-analysis of randomized trials.
Atrial fibrillation (AF) and heart failure (HF) often coexist. We conducted this meta-analysis to assess the efficacy and safety of catheter ablation in this population.Electronic databases were searched for all randomized clinical trials (RCTs) that evaluated catheter ablation in patients with left ventricular systolic dysfunction (LVSD). We calculated the weighted mean differences (MDs) and risk ratios (RRs) using a random-effects model.We included 7 RCTs with 851 patients (mean follow-up was 18 months). Catheter ablation in patients with LVSD was associated with significantly lower HF hospitalization rates (RR 0.57; 95% CI: 0.45-0.72; P < 0.01), reduced all-cause mortality (RR 0.52; 95% CI: 0.35-0.76; P < 0.01), improved left ventricular ejection fraction (MD 7.40; 95% CI: 3.37-11.43; P < 0.01), increased 6-minute walk test (MD 26.96; 95% CI: 6.39-47.54; P = 0.01), and improved peak oxygen consumption (VO2) (MD 3.17; 95% CI: 1.05-5.28; P < 0.01), without significant increased risks of serious adverse events (RR 1.05; 95% CI: 0.96-1.16; P = 0.30) compared with medical treatment.In this meta-analysis of RCTs, catheter ablation was associated with significant improvements in the clinical, structural, and functional capacity of patients with AF and coexisting HF compared with medical treatment.
Duke Scholars
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Related Subject Headings
- Randomized Controlled Trials as Topic
- Humans
- Hospitalization
- Heart Failure
- Catheter Ablation
- Cardiovascular System & Hematology
- Atrial Fibrillation
- 3201 Cardiovascular medicine and haematology
- 1117 Public Health and Health Services
- 1102 Cardiorespiratory Medicine and Haematology
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Start / End Page
Related Subject Headings
- Randomized Controlled Trials as Topic
- Humans
- Hospitalization
- Heart Failure
- Catheter Ablation
- Cardiovascular System & Hematology
- Atrial Fibrillation
- 3201 Cardiovascular medicine and haematology
- 1117 Public Health and Health Services
- 1102 Cardiorespiratory Medicine and Haematology