Skip to main content

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.

Publication ,  Journal Article
van der Kwast, TH; Amin, MB; Billis, A; Epstein, JI; Griffiths, D; Humphrey, PA; Montironi, R; Wheeler, TM; Srigley, JR; Egevad, L; Delahunt, B ...
Published in: Mod Pathol
January 2011

The 2009 International Society of Urological Pathology consensus conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the substaging of pT2 prostate cancers according to the TNM 2002/2010 system, reporting of tumor size/volume and zonal location of prostate cancers were coordinated by working group 2. A survey circulated before the consensus conference demonstrated that 74% of the 157 participants considered pT2 substaging of prostate cancer to be of clinical and/or academic relevance. The survey also revealed a considerable variation in the frequency of reporting of pT2b substage prostate cancer, which was likely a consequence of the variable methodologies used to distinguish pT2a from pT2b tumors. Overview of the literature indicates that current pT2 substaging criteria lack clinical relevance and the majority (65.5%) of conference attendees wished to discontinue pT2 substaging. Therefore, the consensus was that reporting of pT2 substages should, at present, be optional. Several studies have shown that prostate cancer volume is significantly correlated with other clinicopathological features, including Gleason score and extraprostatic extension of tumor; however, most studies fail to demonstrate this to have prognostic significance on multivariate analysis. Consensus was reached with regard to the reporting of some quantitative measure of the volume of tumor in a prostatectomy specimen, without prescribing a specific methodology. Incorporation of the zonal and/or anterior location of the dominant/index tumor in the pathology report was accepted by most participants, but a formal definition of the identifying features of the dominant/index tumor remained undecided.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

January 2011

Volume

24

Issue

1

Start / End Page

16 / 25

Location

United States

Related Subject Headings

  • Specimen Handling
  • Societies, Medical
  • Prostatic Neoplasms
  • Prostatectomy
  • Pathology
  • Neoplasm Staging
  • Male
  • Lymphatic Metastasis
  • Internationality
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
van der Kwast, T. H., Amin, M. B., Billis, A., Epstein, J. I., Griffiths, D., Humphrey, P. A., … ISUP Prostate Cancer Group, . (2011). International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol, 24(1), 16–25. https://doi.org/10.1038/modpathol.2010.156
Kwast, Theo H. van der, Mahul B. Amin, Athanase Billis, Jonathan I. Epstein, David Griffiths, Peter A. Humphrey, Rodolfo Montironi, et al. “International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.Mod Pathol 24, no. 1 (January 2011): 16–25. https://doi.org/10.1038/modpathol.2010.156.
van der Kwast, Theo H., et al. “International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.Mod Pathol, vol. 24, no. 1, Jan. 2011, pp. 16–25. Pubmed, doi:10.1038/modpathol.2010.156.
van der Kwast TH, Amin MB, Billis A, Epstein JI, Griffiths D, Humphrey PA, Montironi R, Wheeler TM, Srigley JR, Egevad L, Delahunt B, ISUP Prostate Cancer Group. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol. 2011 Jan;24(1):16–25.

Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

January 2011

Volume

24

Issue

1

Start / End Page

16 / 25

Location

United States

Related Subject Headings

  • Specimen Handling
  • Societies, Medical
  • Prostatic Neoplasms
  • Prostatectomy
  • Pathology
  • Neoplasm Staging
  • Male
  • Lymphatic Metastasis
  • Internationality
  • Humans