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The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014.

Publication ,  Journal Article
Wei, J; Lu, Y; Li, K; Goodman, M; Xu, H
Published in: Journal of affective disorders
March 2022

Late-life depression has been linked to all-cause and cardiovascular mortality; however, results from previous studies showed heterogeneity. We aimed to examine the associations of late-life depression with all-cause and cardiovascular mortality in a representative sample of the US population.In this prospective cohort study, participants aged 60 years or older in the National Health and Nutrition Examination Survey from 2005 to 2014 with measurement of depressive symptom and information of vital status were included for analysis. The Patient Health Questionnaire (PHQ-9) was used to measure depressive symptoms, and major depression was defined as PHQ-9 score ≥10. Multivariable proportional hazards models were used to examine the associations of depression and depressive symptoms with all-cause and cardiovascular mortality.Among 8,082 participants included in the analysis, 603 (weighted prevalence: 6.1%) had major depression. There were 1,434 deaths from all causes, including 291 deaths from cardiovascular disease during an average follow-up of 63.2 months. After adjustment for covariates, depressive symptoms were associated with higher risk of all-cause and cardiovascular mortality; major depression was associated with increased risk of all-cause (HR=1.52, 95% CI: 1.18, 1.97) and cardiovascular mortality (HR=2.17, 95% CI: 1.36, 3.46).The assessment of depression with self-reported PHQ-9 scale, instead of a clinical diagnosis. Prevalent comorbidities were self-reported, which may raise concerns about misclassification.Late-life depression and its symptoms are associated with increased risk of all-cause and cardiovascular mortality. These findings may inform future studies of late-life depression treatment as a means of reducing mortality.

Duke Scholars

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Published In

Journal of affective disorders

DOI

EISSN

1573-2517

ISSN

0165-0327

Publication Date

March 2022

Volume

300

Start / End Page

189 / 194

Related Subject Headings

  • Psychiatry
  • Prospective Studies
  • Nutrition Surveys
  • Middle Aged
  • Humans
  • Depressive Disorder
  • Depression
  • Cardiovascular Diseases
  • 52 Psychology
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wei, J., Lu, Y., Li, K., Goodman, M., & Xu, H. (2022). The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014. Journal of Affective Disorders, 300, 189–194. https://doi.org/10.1016/j.jad.2021.12.104
Wei, Jingkai, Yifei Lu, Kun Li, Michael Goodman, and Hanzhang Xu. “The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014.Journal of Affective Disorders 300 (March 2022): 189–94. https://doi.org/10.1016/j.jad.2021.12.104.
Wei J, Lu Y, Li K, Goodman M, Xu H. The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014. Journal of affective disorders. 2022 Mar;300:189–94.
Wei, Jingkai, et al. “The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014.Journal of Affective Disorders, vol. 300, Mar. 2022, pp. 189–94. Epmc, doi:10.1016/j.jad.2021.12.104.
Wei J, Lu Y, Li K, Goodman M, Xu H. The associations of late-life depression with all-cause and cardiovascular mortality: The NHANES 2005-2014. Journal of affective disorders. 2022 Mar;300:189–194.
Journal cover image

Published In

Journal of affective disorders

DOI

EISSN

1573-2517

ISSN

0165-0327

Publication Date

March 2022

Volume

300

Start / End Page

189 / 194

Related Subject Headings

  • Psychiatry
  • Prospective Studies
  • Nutrition Surveys
  • Middle Aged
  • Humans
  • Depressive Disorder
  • Depression
  • Cardiovascular Diseases
  • 52 Psychology
  • 42 Health sciences