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Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
Sato, S; Li, N; Dixon, SB; Kato, M; Zhang, H; Li, CK; Howell, RM; Leisenring, WM; Bhatia, S; Oeffinger, KC; Armstrong, GT; Yasui, Y ...
Published in: Cancer Epidemiol Biomarkers Prev
December 2021

BACKGROUND: Given the relatively small population of Asians or Pacific Islanders (API) in the United States, studies describing long-term outcomes in API survivors of childhood cancer are limited. This study compared functional outcomes between API versus non-Hispanic White (NHW) survivors. METHODS: This study included 203 API 5-year survivors [age at follow-up: 29.2 (SD = 6.3) years] and 12,186 NHW survivors [age at follow-up 31.5 (SD = 7.3) years] from the Childhood Cancer Survivor Study. Self-reported functional outcomes of neurocognitive function, emotional distress, quality of life, and social attainment were compared between the two groups using multivariable regression, adjusted for sex, age at diagnosis and evaluation, cancer diagnosis, and neurotoxic treatment. RESULTS: No statistically significant race/ethnicity-based differences were identified in neurocognitive and emotional measures. API survivors reported, on average, less bodily pain than NHW survivors [mean 54.11 (SD = 8.98) vs. 51.32 (SD = 10.12); P < 0.001]. NHW survivors were less likely to have attained at least a college degree than API survivors [OR = 0.50; 95% confidence interval (CI) = 0.34-0.73]. API survivors were more likely than NHW survivors to be never-married (OR = 2.83; 95% CI = 1.93-4.13) and to live dependently (OR = 3.10; 95% CI = 2.02-4.74). Older age (>45 years), brain tumor diagnosis, and higher cranial radiation dose were associated with poorer functional outcomes in API survivors (all, P < 0.05). CONCLUSIONS: We observed differences in social attainment between API and NHW survivors, although statistically significant differences in neurocognitive and emotional outcomes were not identified. IMPACT: Future studies should evaluate whether racial/ethnic differences in environmental and sociocultural factors may have differential effects on health and functional outcomes.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

December 2021

Volume

30

Issue

12

Start / End Page

2244 / 2255

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Siblings
  • Quality of Life
  • Prospective Studies
  • Native Hawaiian or Other Pacific Islander
  • Male
  • Humans
  • Female
  • Epidemiology
 

Citation

APA
Chicago
ICMJE
MLA
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Sato, S., Li, N., Dixon, S. B., Kato, M., Zhang, H., Li, C. K., … Cheung, Y. T. (2021). Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev, 30(12), 2244–2255. https://doi.org/10.1158/1055-9965.EPI-21-0628
Sato, Satomi, Nan Li, Stephanie B. Dixon, Miho Kato, Hui Zhang, Chi Kong Li, Rebecca M. Howell, et al. “Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study.Cancer Epidemiol Biomarkers Prev 30, no. 12 (December 2021): 2244–55. https://doi.org/10.1158/1055-9965.EPI-21-0628.
Sato S, Li N, Dixon SB, Kato M, Zhang H, Li CK, et al. Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2021 Dec;30(12):2244–55.
Sato, Satomi, et al. “Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study.Cancer Epidemiol Biomarkers Prev, vol. 30, no. 12, Dec. 2021, pp. 2244–55. Pubmed, doi:10.1158/1055-9965.EPI-21-0628.
Sato S, Li N, Dixon SB, Kato M, Zhang H, Li CK, Howell RM, Leisenring WM, Bhatia S, Oeffinger KC, Armstrong GT, Yasui Y, Krull KR, Cheung YT. Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2021 Dec;30(12):2244–2255.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

December 2021

Volume

30

Issue

12

Start / End Page

2244 / 2255

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Siblings
  • Quality of Life
  • Prospective Studies
  • Native Hawaiian or Other Pacific Islander
  • Male
  • Humans
  • Female
  • Epidemiology