Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with. Historical and recent works have determined that sensory experiences, particularly during developmental critical periods, are crucial for information processing in the brain, which in turn profoundly influence neuronal and non-neuronal cortical structures that subsequently impact the animals' behavioral and cognitive outputs. In this review, we focus on how altering sensory experience influences normal/healthy development of the central nervous system, particularly focusing on the cerebral cortex using the rodent whisker-to-barrel system as an illustrative model. A better understanding of structural plasticity, encompassing multiple aspects such as neuronal, glial, and extra-cellular domains, provides a more integrative view allowing for a deeper appreciation of how all aspects of the brain work together as a whole.
Duke Scholars
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- 5202 Biological psychology
- 3209 Neurosciences
- 3101 Biochemistry and cell biology
- 1109 Neurosciences
- 0601 Biochemistry and Cell Biology
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Start / End Page
Related Subject Headings
- 5202 Biological psychology
- 3209 Neurosciences
- 3101 Biochemistry and cell biology
- 1109 Neurosciences
- 0601 Biochemistry and Cell Biology