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The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage.

Publication ,  Journal Article
Jaja, BNR; Attalla, D; Macdonald, RL; Schweizer, TA; Cusimano, MD; Etminan, N; Hanggi, D; Hasan, D; Johnston, SC; Le Roux, P; Lo, B; Mayer, S ...
Published in: Neurocrit Care
December 2014

Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.

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Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

December 2014

Volume

21

Issue

3

Start / End Page

551 / 559

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Subarachnoid Hemorrhage
  • Registries
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Neurology & Neurosurgery
  • Humans
  • Databases, Factual
  • Biomedical Research
  • 4205 Nursing
 

Citation

APA
Chicago
ICMJE
MLA
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Jaja, B. N. R., Attalla, D., Macdonald, R. L., Schweizer, T. A., Cusimano, M. D., Etminan, N., … Wong, G. K. C. (2014). The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care, 21(3), 551–559. https://doi.org/10.1007/s12028-014-9990-y
Jaja, Blessing N. R., Daniel Attalla, R Loch Macdonald, Tom A. Schweizer, Michael D. Cusimano, Nima Etminan, Daniel Hanggi, et al. “The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage.Neurocrit Care 21, no. 3 (December 2014): 551–59. https://doi.org/10.1007/s12028-014-9990-y.
Jaja BNR, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, et al. The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care. 2014 Dec;21(3):551–9.
Jaja, Blessing N. R., et al. “The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage.Neurocrit Care, vol. 21, no. 3, Dec. 2014, pp. 551–59. Pubmed, doi:10.1007/s12028-014-9990-y.
Jaja BNR, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MDI, Wong GKC. The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care. 2014 Dec;21(3):551–559.
Journal cover image

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

December 2014

Volume

21

Issue

3

Start / End Page

551 / 559

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Subarachnoid Hemorrhage
  • Registries
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Neurology & Neurosurgery
  • Humans
  • Databases, Factual
  • Biomedical Research
  • 4205 Nursing