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Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.

Publication ,  Journal Article
Gentle, SJ; Carper, B; Laughon, MM; Jensen, EA; Williams, A; Travers, CP; Ambalavanan, N; Lal, CV; Carlo, WA
Published in: J Perinatol
April 2022

OBJECTIVE: To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants. METHODS: Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity. RESULTS: Among 6268 infants 36% developed BPD or died. The median duration of noninvasive respiratory support was 18 days. There was inconsistency in the association between noninvasive support and BPD or death when analyzed by instrumental variable techniques (Average Marginal Effect -0.37; 95% CI -1.23 to 0.50) and generalized propensity score matching (Average Marginal Effect 0.46; 95% CI 0.33 to 0.60). CONCLUSION: Findings on the association between duration of exposure to noninvasive respiratory support and the development of BPD or death were inconclusive. GOV ID: Generic Database:NCT00063063.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

April 2022

Volume

42

Issue

4

Start / End Page

454 / 460

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Respiratory Rate
  • Pediatrics
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age
  • Bronchopulmonary Dysplasia
  • 3213 Paediatrics
 

Citation

APA
Chicago
ICMJE
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Gentle, S. J., Carper, B., Laughon, M. M., Jensen, E. A., Williams, A., Travers, C. P., … Carlo, W. A. (2022). Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. J Perinatol, 42(4), 454–460. https://doi.org/10.1038/s41372-021-01269-2
Gentle, Samuel J., Benjamin Carper, Matthew M. Laughon, Erik A. Jensen, Austin Williams, Colm P. Travers, Namasivayam Ambalavanan, Charitharth V. Lal, and Waldemar A. Carlo. “Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.J Perinatol 42, no. 4 (April 2022): 454–60. https://doi.org/10.1038/s41372-021-01269-2.
Gentle SJ, Carper B, Laughon MM, Jensen EA, Williams A, Travers CP, et al. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. J Perinatol. 2022 Apr;42(4):454–60.
Gentle, Samuel J., et al. “Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death.J Perinatol, vol. 42, no. 4, Apr. 2022, pp. 454–60. Pubmed, doi:10.1038/s41372-021-01269-2.
Gentle SJ, Carper B, Laughon MM, Jensen EA, Williams A, Travers CP, Ambalavanan N, Lal CV, Carlo WA. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. J Perinatol. 2022 Apr;42(4):454–460.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

April 2022

Volume

42

Issue

4

Start / End Page

454 / 460

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Respiratory Rate
  • Pediatrics
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age
  • Bronchopulmonary Dysplasia
  • 3213 Paediatrics