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Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine.

Publication ,  Journal Article
Sun, Y; Locasale, JW
Published in: Cell stress
January 2022

S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing. The importance of SAM is highlighted by its widespread usage as an over-the-counter nutrient supplement and as an experimental reagent in molecular biology. The bioavailability and cellular transport properties of SAM, however, are often overlooked under these contexts, putting limits on SAM's therapeutic potential and complicating the interpretation of experimental results. In this article, we examined the chemical stability and cellular permeability of SAM, proposed a schematic for indirect SAM transport across the mammalian plasma membrane, and lastly discussed the implications arising from such transport schematic.

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Published In

Cell stress

DOI

EISSN

2523-0204

ISSN

2523-0204

Publication Date

January 2022

Volume

6

Issue

1

Start / End Page

1 / 5

Related Subject Headings

  • 3101 Biochemistry and cell biology
 

Citation

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Chicago
ICMJE
MLA
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Sun, Y., & Locasale, J. W. (2022). Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine. Cell Stress, 6(1), 1–5. https://doi.org/10.15698/cst2022.01.261
Sun, Yudong, and Jason W. Locasale. “Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine.Cell Stress 6, no. 1 (January 2022): 1–5. https://doi.org/10.15698/cst2022.01.261.
Sun, Yudong, and Jason W. Locasale. “Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine.Cell Stress, vol. 6, no. 1, Jan. 2022, pp. 1–5. Epmc, doi:10.15698/cst2022.01.261.

Published In

Cell stress

DOI

EISSN

2523-0204

ISSN

2523-0204

Publication Date

January 2022

Volume

6

Issue

1

Start / End Page

1 / 5

Related Subject Headings

  • 3101 Biochemistry and cell biology