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Microenvironmental influences on T cell immunity in cancer and inflammation.

Publication ,  Journal Article
Heintzman, DR; Fisher, EL; Rathmell, JC
Published in: Cellular & molecular immunology
March 2022

T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must function in a wide variety of tissue settings, and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing importance. Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity. These include fever and increased temperatures, depletion of critical micro and macro-nutrients, and accumulation of inhibitory waste products. Here we review several of these factors and how the tissue microenvironment both shapes and constrains immunity.

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Published In

Cellular & molecular immunology

DOI

EISSN

2042-0226

ISSN

1672-7681

Publication Date

March 2022

Volume

19

Issue

3

Start / End Page

316 / 326

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocyte Subsets
  • Neoplasms
  • Inflammation
  • Immunology
  • Humans
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology
 

Citation

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ICMJE
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Heintzman, D. R., Fisher, E. L., & Rathmell, J. C. (2022). Microenvironmental influences on T cell immunity in cancer and inflammation. Cellular & Molecular Immunology, 19(3), 316–326. https://doi.org/10.1038/s41423-021-00833-2
Heintzman, Darren R., Emilie L. Fisher, and Jeffrey C. Rathmell. “Microenvironmental influences on T cell immunity in cancer and inflammation.Cellular & Molecular Immunology 19, no. 3 (March 2022): 316–26. https://doi.org/10.1038/s41423-021-00833-2.
Heintzman DR, Fisher EL, Rathmell JC. Microenvironmental influences on T cell immunity in cancer and inflammation. Cellular & molecular immunology. 2022 Mar;19(3):316–26.
Heintzman, Darren R., et al. “Microenvironmental influences on T cell immunity in cancer and inflammation.Cellular & Molecular Immunology, vol. 19, no. 3, Mar. 2022, pp. 316–26. Epmc, doi:10.1038/s41423-021-00833-2.
Heintzman DR, Fisher EL, Rathmell JC. Microenvironmental influences on T cell immunity in cancer and inflammation. Cellular & molecular immunology. 2022 Mar;19(3):316–326.

Published In

Cellular & molecular immunology

DOI

EISSN

2042-0226

ISSN

1672-7681

Publication Date

March 2022

Volume

19

Issue

3

Start / End Page

316 / 326

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocyte Subsets
  • Neoplasms
  • Inflammation
  • Immunology
  • Humans
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology