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Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting

Publication ,  Journal Article
Bouganim, N; Dranitsaris, G; Hopkins, S; Vandermeer, L; Godbout, L; Dent, S; Wheatley-Price, P; Milano, C; Clemons, M
Published in: Current Oncology
January 1, 2012

Background Despite the use of standardized anti-emetic guidelines, up to 20% of cancer patients suffer from moderate-to-severe chemotherapy-induced nausea and vomiting (CINV)-that is, grade 2 or greater according to the U.S. National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. We previously developed cycle-based prediction models and associated scoring systems for acute and delayed CINV. As part of the validation process, we prospectively evaluated the ability of the scoring systems to accurately identify patients deemed to be high risk for grade 2 or greater CINV. Methods Patients who were receiving any chemotherapy for solid tumours and who consented to participate were provided with symptom diaries. Compliance to the diaries was enhanced by 24-hour and 5-day telephone callbacks after chemotherapy in every cycle. All patients received anti-emetic prophylaxis as prescribed by the treating physician. Before each cycle of chemotherapy, the acute and delayed CINV scoring systems were used to stratify patients into low- and high-risk groups. Logistic regression modelling was then applied to compare the risk for grade 2 or greater CINV between patients considered to be at high and at low risk. The external validity of each system was also assessed using an area under the receiver operating characteristic curve (AUROC) analysis. Results We collected CINV outcomes data from 95 patients during 181 cycles of chemotherapy. The incidence of grade 2 or greater acute and delayed CINV was 17.7% and 18.2% respectively. As previously identified, major predictors for grade 2 or greater CINV included younger patient age, platinumor anthracyclinebased chemotherapy, low alcohol consumption, earlier cycles of chemotherapy, previous history of morning sickness, and prior emetic episodes after chemotherapy. The acute and delayed scoring systems both had good predictive accuracy when applied to the external validation sample (acute- AUROC: 0.69; 95% confidence interval: 0.59 to 0.79; delayed-AUROC: 0.70; 95% confidence interval: 0.60 to 0.80). Patients identified by the scoring systems to be at high risk were 2.8 (p = 0.025) and 3.1 (p = 0.001) times more likely to develop grade 2 or greater acute and delayed CINV. Conclusions The present study demonstrates that our scoring systems are able to accurately identify patients at high risk for acute and delayed CINV. Application and planned continued refinement of the scoring systems will be an important means of patient-specific risk assessment that will allow for optimization of antiemetic therapy. © 2012 Multimed Inc.

Duke Scholars

Published In

Current Oncology

DOI

EISSN

1718-7729

Publication Date

January 1, 2012

Volume

19

Issue

6

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bouganim, N., Dranitsaris, G., Hopkins, S., Vandermeer, L., Godbout, L., Dent, S., … Clemons, M. (2012). Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting. Current Oncology, 19(6). https://doi.org/10.3747/co.19.1074
Bouganim, N., G. Dranitsaris, S. Hopkins, L. Vandermeer, L. Godbout, S. Dent, P. Wheatley-Price, C. Milano, and M. Clemons. “Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting.” Current Oncology 19, no. 6 (January 1, 2012). https://doi.org/10.3747/co.19.1074.
Bouganim N, Dranitsaris G, Hopkins S, Vandermeer L, Godbout L, Dent S, et al. Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting. Current Oncology. 2012 Jan 1;19(6).
Bouganim, N., et al. “Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting.” Current Oncology, vol. 19, no. 6, Jan. 2012. Scopus, doi:10.3747/co.19.1074.
Bouganim N, Dranitsaris G, Hopkins S, Vandermeer L, Godbout L, Dent S, Wheatley-Price P, Milano C, Clemons M. Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting. Current Oncology. 2012 Jan 1;19(6).

Published In

Current Oncology

DOI

EISSN

1718-7729

Publication Date

January 1, 2012

Volume

19

Issue

6

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis