Body temperature-dependent and independent actions of chlordimeform on visual evoked potentials and axonal transport in optic system of rat.
Pattern-reversal-evoked potentials (PREPs), flash-evoked potentials (FEPs), rapid axonal transport in the optic system and body temperature were measured in hooded rats, treated with either saline or the formamidine insecticide/acaricide, chlordimeform (CDM). Rats receiving chlordimeform had low body temperatures when housed at standard laboratory room temperature, 22 degrees C, but not at 30 degrees C. Peak latencies of flash-evoked potentials were prolonged by chlordimeform at 22 degrees C, but not at 30 degrees C. The rate of axonal transport was slowed in chlordimeform-treated hypothermic rats, but not in chlordimeform-treated warmed rats. These findings suggest that the flash-evoked potential and axonal transport changes produced by chlordimeform were an indirect consequence of hypothermia. In contrast, chlordimeform increased pattern-reversal evoked potential peak latencies and peak-to-peak amplitudes independent of body temperature. These findings confirm and extend previous reports of chlordimeform-induced hypothermia, emphasize the importance of changes in body temperature as a possible confounding factor in studies of neuroactive agents and demonstrate that chlordimeform has both body-temperature-dependent and independent actions in the visual system in the rat.
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Related Subject Headings
- Retina
- Rats
- Neurology & Neurosurgery
- Male
- Glycoproteins
- Evoked Potentials, Visual
- Chlorphenamidine
- Body Temperature
- Axonal Transport
- Animals
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Retina
- Rats
- Neurology & Neurosurgery
- Male
- Glycoproteins
- Evoked Potentials, Visual
- Chlorphenamidine
- Body Temperature
- Axonal Transport
- Animals