Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans.
Publication
, Journal Article
Missall, TA; Lodge, JK
Published in: Eukaryot Cell
February 2005
Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway. Here we show that it is induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans. The C. neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little homology with that of its mammalian host. By replacing the endogenous TRR1 promoter with an inducible copper transporter promoter, we showed that Trr1 appears to be essential for viability of this pathogenic fungus, making it a potential antifungal target.
Duke Scholars
Published In
Eukaryot Cell
DOI
ISSN
1535-9778
Publication Date
February 2005
Volume
4
Issue
2
Start / End Page
487 / 489
Location
United States
Related Subject Headings
- Thioredoxin-Disulfide Reductase
- Recombinant Fusion Proteins
- Reactive Nitrogen Species
- Promoter Regions, Genetic
- Oxidative Stress
- Mitochondria
- Microbiology
- Isoenzymes
- Fungal Proteins
- Cryptococcus neoformans
Citation
APA
Chicago
ICMJE
MLA
NLM
Missall, T. A., & Lodge, J. K. (2005). Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. Eukaryot Cell, 4(2), 487–489. https://doi.org/10.1128/EC.4.2.487-489.2005
Missall, Tricia A., and Jennifer K. Lodge. “Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans.” Eukaryot Cell 4, no. 2 (February 2005): 487–89. https://doi.org/10.1128/EC.4.2.487-489.2005.
Missall TA, Lodge JK. Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. Eukaryot Cell. 2005 Feb;4(2):487–9.
Missall, Tricia A., and Jennifer K. Lodge. “Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans.” Eukaryot Cell, vol. 4, no. 2, Feb. 2005, pp. 487–89. Pubmed, doi:10.1128/EC.4.2.487-489.2005.
Missall TA, Lodge JK. Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. Eukaryot Cell. 2005 Feb;4(2):487–489.
Published In
Eukaryot Cell
DOI
ISSN
1535-9778
Publication Date
February 2005
Volume
4
Issue
2
Start / End Page
487 / 489
Location
United States
Related Subject Headings
- Thioredoxin-Disulfide Reductase
- Recombinant Fusion Proteins
- Reactive Nitrogen Species
- Promoter Regions, Genetic
- Oxidative Stress
- Mitochondria
- Microbiology
- Isoenzymes
- Fungal Proteins
- Cryptococcus neoformans