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Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.

Publication ,  Journal Article
Ferrufino-Schmidt, MC; Medeiros, LJ; Liu, H; Clemens, MW; Hunt, KK; Laurent, C; Lofts, J; Amin, MB; Ming Chai, S; Morine, A; Di Napoli, A ...
Published in: Am J Surg Pathol
March 2018

Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P=0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall.

Duke Scholars

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Published In

Am J Surg Pathol

DOI

EISSN

1532-0979

Publication Date

March 2018

Volume

42

Issue

3

Start / End Page

293 / 305

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Pathology
  • Middle Aged
  • Lymphoma, Large-Cell, Anaplastic
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Hodgkin Disease
  • Female
 

Citation

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Chicago
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MLA
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Ferrufino-Schmidt, M. C., Medeiros, L. J., Liu, H., Clemens, M. W., Hunt, K. K., Laurent, C., … Miranda, R. N. (2018). Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol, 42(3), 293–305. https://doi.org/10.1097/PAS.0000000000000985
Ferrufino-Schmidt, Maria C., L Jeffrey Medeiros, Hui Liu, Mark W. Clemens, Kelly K. Hunt, Camille Laurent, Julian Lofts, et al. “Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.Am J Surg Pathol 42, no. 3 (March 2018): 293–305. https://doi.org/10.1097/PAS.0000000000000985.
Ferrufino-Schmidt MC, Medeiros LJ, Liu H, Clemens MW, Hunt KK, Laurent C, et al. Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol. 2018 Mar;42(3):293–305.
Ferrufino-Schmidt, Maria C., et al. “Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.Am J Surg Pathol, vol. 42, no. 3, Mar. 2018, pp. 293–305. Pubmed, doi:10.1097/PAS.0000000000000985.
Ferrufino-Schmidt MC, Medeiros LJ, Liu H, Clemens MW, Hunt KK, Laurent C, Lofts J, Amin MB, Ming Chai S, Morine A, Di Napoli A, Dogan A, Parkash V, Bhagat G, Tritz D, Quesada AE, Pina-Oviedo S, Hu Q, Garcia-Gomez FJ, Jose Borrero J, Horna P, Thakral B, Narbaitz M, Hughes RC, Yang L-J, Fromm JR, Wu D, Zhang D, Sohani AR, Hunt J, Vadlamani IU, Morgan EA, Ferry JA, Szigeti R, C Tardio J, Granados R, Dertinger S, Offner FA, Pircher A, Hosry J, Young KH, Miranda RN. Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol. 2018 Mar;42(3):293–305.

Published In

Am J Surg Pathol

DOI

EISSN

1532-0979

Publication Date

March 2018

Volume

42

Issue

3

Start / End Page

293 / 305

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Pathology
  • Middle Aged
  • Lymphoma, Large-Cell, Anaplastic
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Hodgkin Disease
  • Female