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NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.

Publication ,  Journal Article
Yu, L; Li, L; Medeiros, LJ; Young, KH
Published in: Blood Rev
March 2017

The NF-κB pathway, a critical regulator of apoptosis, plays a key role in many normal cellular functions. Genetic alterations and other mechanisms leading to constitutive activation of the NF-κB pathway contribute to cancer development, progression and therapy resistance by activation of downstream anti-apoptotic pathways, unfavorable microenvironment interactions, and gene dysregulation. Not surprisingly, given its importance to normal and cancer cell function, the NF-κB pathway has emerged as a target for therapy. In the review, we present the physiologic role of the NF-κB pathway and recent advances in better understanding of the pathologic roles of the NF-κB pathway in major types of lymphoid neoplasms. We also provide an update of clinical trials that use NF-κB pathway inhibitors. These trials are exploring the clinical efficiency of combining NF-κB pathway inhibitors with various agents that target diverse mechanisms of action with the goal being to optimize novel therapeutic opportunities for targeting oncogenic pathways to eradicate cancer cells.

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Published In

Blood Rev

DOI

EISSN

1532-1681

Publication Date

March 2017

Volume

31

Issue

2

Start / End Page

77 / 92

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Treatment Outcome
  • Signal Transduction
  • NF-kappa B
  • Mutation
  • Molecular Targeted Therapy
  • Lymphoma
  • Lymphoid Tissue
  • Leukemia, Lymphoid
  • Immunology
 

Citation

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Yu, L., Li, L., Medeiros, L. J., & Young, K. H. (2017). NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms. Blood Rev, 31(2), 77–92. https://doi.org/10.1016/j.blre.2016.10.001
Yu, Li, Ling Li, L Jeffrey Medeiros, and Ken H. Young. “NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.Blood Rev 31, no. 2 (March 2017): 77–92. https://doi.org/10.1016/j.blre.2016.10.001.
Yu L, Li L, Medeiros LJ, Young KH. NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms. Blood Rev. 2017 Mar;31(2):77–92.
Yu, Li, et al. “NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.Blood Rev, vol. 31, no. 2, Mar. 2017, pp. 77–92. Pubmed, doi:10.1016/j.blre.2016.10.001.
Yu L, Li L, Medeiros LJ, Young KH. NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms. Blood Rev. 2017 Mar;31(2):77–92.
Journal cover image

Published In

Blood Rev

DOI

EISSN

1532-1681

Publication Date

March 2017

Volume

31

Issue

2

Start / End Page

77 / 92

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Treatment Outcome
  • Signal Transduction
  • NF-kappa B
  • Mutation
  • Molecular Targeted Therapy
  • Lymphoma
  • Lymphoid Tissue
  • Leukemia, Lymphoid
  • Immunology