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Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.

Publication ,  Journal Article
Clemens, MW; Medeiros, LJ; Butler, CE; Hunt, KK; Fanale, MA; Horwitz, S; Weisenburger, DD; Liu, J; Morgan, EA; Kanagal-Shamanna, R; Parkash, V ...
Published in: J Clin Oncol
January 10, 2016

PURPOSE: Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a rare type of T-cell lymphoma that arises around breast implants. The optimal management of this disease has not been established. The goal of this study is to evaluate the efficacy of different therapies used in patients with BI-ALCL to determine an optimal treatment approach. PATIENTS AND METHODS: In this study, we applied strict criteria to pathologic findings, assessed therapies used, and conducted a clinical follow-up of 87 patients with BI-ALCL, including 50 previously reported in the literature and 37 unreported. A Prentice, Williams, and Peterson model was used to assess the rate of events for each therapeutic intervention. RESULTS: The median and mean follow-up times were 45 and 30 months, respectively (range, 3 to 217 months). The median overall survival (OS) time after diagnosis of BI-ALCL was 13 years, and the OS rate was 93% and 89% at 3 and 5 years, respectively. Patients with lymphoma confined by the fibrous capsule surrounding the implant had better event-free survival (EFS) and OS than did patients with lymphoma that had spread beyond the capsule (P = .03). Patients who underwent a complete surgical excision that consisted of total capsulectomy with breast implant removal had better OS (P = .022) and EFS (P = .014) than did patients who received partial capsulectomy, systemic chemotherapy, or radiation therapy. CONCLUSION: Surgical management with complete surgical excision is essential to achieve optimal EFS in patients with BI-ALCL.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 10, 2016

Volume

34

Issue

2

Start / End Page

160 / 168

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphoma, Large-Cell, Anaplastic
  • Kaplan-Meier Estimate
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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Chicago
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Clemens, M. W., Medeiros, L. J., Butler, C. E., Hunt, K. K., Fanale, M. A., Horwitz, S., … Miranda, R. N. (2016). Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. J Clin Oncol, 34(2), 160–168. https://doi.org/10.1200/JCO.2015.63.3412
Clemens, Mark W., L Jeffrey Medeiros, Charles E. Butler, Kelly K. Hunt, Michelle A. Fanale, Steven Horwitz, Dennis D. Weisenburger, et al. “Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.J Clin Oncol 34, no. 2 (January 10, 2016): 160–68. https://doi.org/10.1200/JCO.2015.63.3412.
Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, et al. Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. J Clin Oncol. 2016 Jan 10;34(2):160–8.
Clemens, Mark W., et al. “Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.J Clin Oncol, vol. 34, no. 2, Jan. 2016, pp. 160–68. Pubmed, doi:10.1200/JCO.2015.63.3412.
Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, Weisenburger DD, Liu J, Morgan EA, Kanagal-Shamanna R, Parkash V, Ning J, Sohani AR, Ferry JA, Mehta-Shah N, Dogan A, Liu H, Thormann N, Di Napoli A, Lade S, Piccolini J, Reyes R, Williams T, McCarthy CM, Hanson SE, Nastoupil LJ, Gaur R, Oki Y, Young KH, Miranda RN. Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. J Clin Oncol. 2016 Jan 10;34(2):160–168.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 10, 2016

Volume

34

Issue

2

Start / End Page

160 / 168

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphoma, Large-Cell, Anaplastic
  • Kaplan-Meier Estimate
  • Humans
  • Follow-Up Studies
  • Female