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TP53 dysfunction in diffuse large B-cell lymphoma.

Publication ,  Journal Article
Lu, T-X; Young, KH; Xu, W; Li, J-Y
Published in: Crit Rev Oncol Hematol
January 2016

The aberrations of TP53 gene and dysregulation of the TP53 pathway are important in the pathogenesis of many human cancers, including malignant lymphomas, especially for diffuse large B cell lymphoma (DLBCL). By regulating many downstream target genes or molecules, TP53 governs major defenses against tumor growth and promotes cellular DNA repair, apoptosis, autophagy, cell cycle arrest, signaling, transcription, immune or inflammatory responses and metabolism. Dysfunction of TP53, including microRNA regulations, copy number alterations of TP53 pathway and TP53 itself, dysregulation of TP53 regulators, and somatic mutations by abnormal TP53 function modes, play an important role in lymphoma generation, progression and invasion. The role of TP53 in DLBCL has been widely explored recently. In this review, we summarized recent advances on different mechanisms of TP53 in DLBCL and new therapeutic approaches to overcome TP53 inactivation.

Duke Scholars

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Published In

Crit Rev Oncol Hematol

DOI

EISSN

1879-0461

Publication Date

January 2016

Volume

97

Start / End Page

47 / 55

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Oncology & Carcinogenesis
  • MicroRNAs
  • Lymphoma, Large B-Cell, Diffuse
  • Inflammation
  • Immunity, Cellular
  • Humans
  • Genes, p53
  • Gene Silencing
  • Gene Expression Regulation, Neoplastic
 

Citation

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Lu, T.-X., Young, K. H., Xu, W., & Li, J.-Y. (2016). TP53 dysfunction in diffuse large B-cell lymphoma. Crit Rev Oncol Hematol, 97, 47–55. https://doi.org/10.1016/j.critrevonc.2015.08.006
Lu, Ting-Xun, Ken H. Young, Wei Xu, and Jian-Yong Li. “TP53 dysfunction in diffuse large B-cell lymphoma.Crit Rev Oncol Hematol 97 (January 2016): 47–55. https://doi.org/10.1016/j.critrevonc.2015.08.006.
Lu T-X, Young KH, Xu W, Li J-Y. TP53 dysfunction in diffuse large B-cell lymphoma. Crit Rev Oncol Hematol. 2016 Jan;97:47–55.
Lu, Ting-Xun, et al. “TP53 dysfunction in diffuse large B-cell lymphoma.Crit Rev Oncol Hematol, vol. 97, Jan. 2016, pp. 47–55. Pubmed, doi:10.1016/j.critrevonc.2015.08.006.
Lu T-X, Young KH, Xu W, Li J-Y. TP53 dysfunction in diffuse large B-cell lymphoma. Crit Rev Oncol Hematol. 2016 Jan;97:47–55.
Journal cover image

Published In

Crit Rev Oncol Hematol

DOI

EISSN

1879-0461

Publication Date

January 2016

Volume

97

Start / End Page

47 / 55

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Oncology & Carcinogenesis
  • MicroRNAs
  • Lymphoma, Large B-Cell, Diffuse
  • Inflammation
  • Immunity, Cellular
  • Humans
  • Genes, p53
  • Gene Silencing
  • Gene Expression Regulation, Neoplastic