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Genetic lesions in diffuse large B-cell lymphomas.

Publication ,  Journal Article
Testoni, M; Zucca, E; Young, KH; Bertoni, F
Published in: Ann Oncol
June 2015

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults, accounting for 35%-40% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab with anthracycline-based combination chemotherapy (R-CHOP, rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) lead to complete remission in most and can cure more than half of patients with DLBCL. The diversity in clinical presentation, as well as the pathologic and biologic heterogeneity, suggests that DLBCL comprises several disease entities that might ultimately benefit from different therapeutic approaches. In this review, we summarize the current literature focusing on the genetic lesions identified in DLBCL.

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Published In

Ann Oncol

DOI

EISSN

1569-8041

Publication Date

June 2015

Volume

26

Issue

6

Start / End Page

1069 / 1080

Location

England

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Remission Induction
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Pharmacogenetics
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Lymphoma, Large B-Cell, Diffuse
 

Citation

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Testoni, M., Zucca, E., Young, K. H., & Bertoni, F. (2015). Genetic lesions in diffuse large B-cell lymphomas. Ann Oncol, 26(6), 1069–1080. https://doi.org/10.1093/annonc/mdv019
Testoni, M., E. Zucca, K. H. Young, and F. Bertoni. “Genetic lesions in diffuse large B-cell lymphomas.Ann Oncol 26, no. 6 (June 2015): 1069–80. https://doi.org/10.1093/annonc/mdv019.
Testoni M, Zucca E, Young KH, Bertoni F. Genetic lesions in diffuse large B-cell lymphomas. Ann Oncol. 2015 Jun;26(6):1069–80.
Testoni, M., et al. “Genetic lesions in diffuse large B-cell lymphomas.Ann Oncol, vol. 26, no. 6, June 2015, pp. 1069–80. Pubmed, doi:10.1093/annonc/mdv019.
Testoni M, Zucca E, Young KH, Bertoni F. Genetic lesions in diffuse large B-cell lymphomas. Ann Oncol. 2015 Jun;26(6):1069–1080.
Journal cover image

Published In

Ann Oncol

DOI

EISSN

1569-8041

Publication Date

June 2015

Volume

26

Issue

6

Start / End Page

1069 / 1080

Location

England

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Remission Induction
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Pharmacogenetics
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Lymphoma, Large B-Cell, Diffuse