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EBV-positive diffuse large B-cell lymphoma of the elderly.

Publication ,  Journal Article
Ok, CY; Papathomas, TG; Medeiros, LJ; Young, KH
Published in: Blood
July 18, 2013

Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly, initially described in 2003, is a provisional entity in the 2008 World Health Organization classification system and is defined as an EBV-positive monoclonal large B-cell proliferation that occurs in patients >50 years of age and in whom there is no known immunodeficiency or history of lymphoma. These tumors are more common in Asia but also occur in North America and Europe at a low frequency. These neoplasms exhibit a morphologic continuum, from polymorphous to monomorphous, but morphologic features do not correlate with prognosis as all patients have a clinically aggressive course. Most EBV-positive DLBCL of the elderly patients have an activated B-cell immunophenotype and are characterized by prominent nuclear factor-κB activation. Cytogenetic complexity is usually low. In this review, we comprehensively delineate the data emerging from analyses of EBV latency program, microRNA-mediated EBV viral oncogenesis, functional genomics of EBV and its biology, and differential diagnosis challenge for EBV-positive DLBCL of the elderly. It is hoped that the improved understanding of these tumors will lead to the development of novel therapeutic approaches, enhance the effectiveness of clinical trials, and improve prognosis.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

July 18, 2013

Volume

122

Issue

3

Start / End Page

328 / 340

Location

United States

Related Subject Headings

  • Models, Biological
  • MicroRNAs
  • Lymphoma, Large B-Cell, Diffuse
  • Immunophenotyping
  • Immunology
  • Humans
  • Herpesvirus 4, Human
  • Epstein-Barr Virus Infections
  • Aged
  • 3213 Paediatrics
 

Citation

APA
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Ok, C. Y., Papathomas, T. G., Medeiros, L. J., & Young, K. H. (2013). EBV-positive diffuse large B-cell lymphoma of the elderly. Blood, 122(3), 328–340. https://doi.org/10.1182/blood-2013-03-489708
Ok, Chi Young, Thomas G. Papathomas, L Jeffrey Medeiros, and Ken H. Young. “EBV-positive diffuse large B-cell lymphoma of the elderly.Blood 122, no. 3 (July 18, 2013): 328–40. https://doi.org/10.1182/blood-2013-03-489708.
Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. 2013 Jul 18;122(3):328–40.
Ok, Chi Young, et al. “EBV-positive diffuse large B-cell lymphoma of the elderly.Blood, vol. 122, no. 3, July 2013, pp. 328–40. Pubmed, doi:10.1182/blood-2013-03-489708.
Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. 2013 Jul 18;122(3):328–340.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

July 18, 2013

Volume

122

Issue

3

Start / End Page

328 / 340

Location

United States

Related Subject Headings

  • Models, Biological
  • MicroRNAs
  • Lymphoma, Large B-Cell, Diffuse
  • Immunophenotyping
  • Immunology
  • Humans
  • Herpesvirus 4, Human
  • Epstein-Barr Virus Infections
  • Aged
  • 3213 Paediatrics