Skip to main content
Journal cover image

Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas.

Publication ,  Journal Article
Hu, S; Young, KH; Konoplev, SN; Medeiros, LJ
Published in: Hum Pathol
November 2012

Unlike B-cell lymphomas, where knowledge of normal B-cell origin and differentiation has greatly contributed to their classification, the current classification of peripheral T-cell lymphomas is limited by a lack of understanding of their cellular origin. In the current World Health Organization classification of lymphomas, follicular T-cell lymphoma was formally recognized as a morphologic variant of peripheral T-cell lymphoma, not otherwise specified. There is growing evidence, however, that follicular T-cell lymphoma may be a unique clinicopathologic entity based on its morphologic features and derivation from follicular helper T-cells. In addition, there are abundant recent data supporting the concept that follicular helper T-cells can give rise to other types of T-cell lymphoma, including angioimmunoblastic T-cell lymphoma, primary cutaneous CD4+ small/medium T-cell lymphoma, and a subset of neoplasms, in addition to follicular T-cell lymphoma, currently classified as peripheral T-cell lymphoma, not otherwise specified. In this review, we focus primarily on the clinicopathologic, immunophenotypic, and molecular features of follicular T-cell lymphoma and discuss its potential relationship with other types of T-cell lymphoma thought to be derived from follicular helper T-cells.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

November 2012

Volume

43

Issue

11

Start / End Page

1789 / 1798

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Pathology
  • Lymphoma, T-Cell, Peripheral
  • Lymphoma, Follicular
  • Lymph Nodes
  • Immunophenotyping
  • Humans
  • Gene Rearrangement, T-Lymphocyte
  • DNA, Neoplasm
  • Abnormal Karyotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, S., Young, K. H., Konoplev, S. N., & Medeiros, L. J. (2012). Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Hum Pathol, 43(11), 1789–1798. https://doi.org/10.1016/j.humpath.2012.05.002
Hu, Shimin, Ken H. Young, Sergej N. Konoplev, and L Jeffrey Medeiros. “Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas.Hum Pathol 43, no. 11 (November 2012): 1789–98. https://doi.org/10.1016/j.humpath.2012.05.002.
Hu S, Young KH, Konoplev SN, Medeiros LJ. Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Hum Pathol. 2012 Nov;43(11):1789–98.
Hu, Shimin, et al. “Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas.Hum Pathol, vol. 43, no. 11, Nov. 2012, pp. 1789–98. Pubmed, doi:10.1016/j.humpath.2012.05.002.
Hu S, Young KH, Konoplev SN, Medeiros LJ. Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. Hum Pathol. 2012 Nov;43(11):1789–1798.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

November 2012

Volume

43

Issue

11

Start / End Page

1789 / 1798

Location

United States

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Pathology
  • Lymphoma, T-Cell, Peripheral
  • Lymphoma, Follicular
  • Lymph Nodes
  • Immunophenotyping
  • Humans
  • Gene Rearrangement, T-Lymphocyte
  • DNA, Neoplasm
  • Abnormal Karyotype