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EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.

Publication ,  Journal Article
Montes-Moreno, S; Odqvist, L; Diaz-Perez, JA; Lopez, AB; de Villambrosía, SG; Mazorra, F; Castillo, ME; Lopez, M; Pajares, R; García, JF ...
Published in: Mod Pathol
July 2012

Here, we report a retrospective series of 47 EBV-positive diffuse large B-cell lymphoma associated with advanced age. Histopathology allowed to the identification of different histological patterns: cases with polymorphic diffuse large B-cell lymphoma (29 cases), Hodgkin-like (8 cases) and polymorphic lymphoproliferative disorder-like (9 cases) patterns. One case was purely monomorphic diffuse large B-cell lymphoma. We show that this lymphoma type is a neoplasm with prominent classical and alternative nuclear factor-kB pathway activation in neoplastic cells (79% of the cases showed nuclear staining for p105/p50, 74% for p100/p52 and 63% for both proteins), with higher frequency than that observed in a control series of EBV-negative diffuse large B-cell lymphoma (χ(2) <0.001). Most cases showed an activated phenotype (95% non-germinal center (Hans algorithm); 78% activated B cell (Choi algorithm)). Clonality testing demonstrated IgH and/or K/Kde/L monoclonal rearrangements in 64% of cases and clonal T-cell populations in 24% of cases. C-MYC (1 case), BCL6 (2 cases) or IgH (3 cases) translocations were detected by FISH in 18% cases. These tumors had a poor overall survival and progression-free survival (the estimated 2-year overall survival was 40 ± 10% and the estimated 2-year progression-free survival was 36 ± 9%). Thus, alternative therapies, based on the tumor biology, need to be tested in patients with EBV-positive diffuse large B-cell lymphoma of the elderly.

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Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

July 2012

Volume

25

Issue

7

Start / End Page

968 / 982

Location

United States

Related Subject Headings

  • Tissue Array Analysis
  • Retrospective Studies
  • Pathology
  • Neoplasm Staging
  • NF-kappa B
  • Middle Aged
  • Lymphoma, Large B-Cell, Diffuse
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry
  • Humans
 

Citation

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Montes-Moreno, S., Odqvist, L., Diaz-Perez, J. A., Lopez, A. B., de Villambrosía, S. G., Mazorra, F., … Piris, M. A. (2012). EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation. Mod Pathol, 25(7), 968–982. https://doi.org/10.1038/modpathol.2012.52
Montes-Moreno, Santiago, Lina Odqvist, Julio A. Diaz-Perez, Ana Batlle Lopez, Sonia Gonzalez de Villambrosía, Francisco Mazorra, Maria E. Castillo, et al. “EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.Mod Pathol 25, no. 7 (July 2012): 968–82. https://doi.org/10.1038/modpathol.2012.52.
Montes-Moreno S, Odqvist L, Diaz-Perez JA, Lopez AB, de Villambrosía SG, Mazorra F, et al. EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation. Mod Pathol. 2012 Jul;25(7):968–82.
Montes-Moreno, Santiago, et al. “EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.Mod Pathol, vol. 25, no. 7, July 2012, pp. 968–82. Pubmed, doi:10.1038/modpathol.2012.52.
Montes-Moreno S, Odqvist L, Diaz-Perez JA, Lopez AB, de Villambrosía SG, Mazorra F, Castillo ME, Lopez M, Pajares R, García JF, Mollejo M, Camacho FI, Ruiz-Marcellán C, Adrados M, Ortiz N, Franco R, Ortiz-Hidalgo C, Suarez-Gauthier A, Young KH, Piris MA. EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation. Mod Pathol. 2012 Jul;25(7):968–982.

Published In

Mod Pathol

DOI

EISSN

1530-0285

Publication Date

July 2012

Volume

25

Issue

7

Start / End Page

968 / 982

Location

United States

Related Subject Headings

  • Tissue Array Analysis
  • Retrospective Studies
  • Pathology
  • Neoplasm Staging
  • NF-kappa B
  • Middle Aged
  • Lymphoma, Large B-Cell, Diffuse
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry
  • Humans