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NOX enzymes and pulmonary disease.

Publication ,  Journal Article
Griffith, B; Pendyala, S; Hecker, L; Lee, PJ; Natarajan, V; Thannickal, VJ
Published in: Antioxidants & redox signaling
October 2009

The primary function of the lung is to facilitate the transfer of molecular oxygen (O(2); dioxygen) from the atmosphere to the systemic circulation. In addition to its essential role in aerobic metabolism, O(2) serves as the physiologic terminal acceptor of electron transfer catalyzed by the NADPH oxidase (NOX) family of oxidoreductases. The evolution of the lungs and circulatory systems in vertebrates was accompanied by increasing diversification of NOX family enzymes, suggesting adaptive roles for NOX-derived reactive oxygen species in normal physiology. However, this adaptation may paradoxically carry detrimental consequences in the setting of overwhelming/persistent environmental stressors, both infectious and noninfectious, and during the process of aging. Here, we review current understanding of NOX enzymes in normal lung physiology and their pathophysiologic roles in a number of pulmonary diseases, including lung infections, acute lung injury, pulmonary arterial hypertension, obstructive lung disorders, fibrotic lung disease, and lung cancer.

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Published In

Antioxidants & redox signaling

DOI

EISSN

1557-7716

ISSN

1523-0864

Publication Date

October 2009

Volume

11

Issue

10

Start / End Page

2505 / 2516

Related Subject Headings

  • Respiratory System
  • Reperfusion Injury
  • Reactive Oxygen Species
  • NADPH Oxidases
  • Lung Neoplasms
  • Lung Diseases
  • Isoenzymes
  • Hypertension
  • Humans
  • Fibrosis
 

Citation

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Griffith, B., Pendyala, S., Hecker, L., Lee, P. J., Natarajan, V., & Thannickal, V. J. (2009). NOX enzymes and pulmonary disease. Antioxidants & Redox Signaling, 11(10), 2505–2516. https://doi.org/10.1089/ars.2009.2599
Griffith, Brian, Srikanth Pendyala, Louise Hecker, Patty J. Lee, Viswanathan Natarajan, and Victor J. Thannickal. “NOX enzymes and pulmonary disease.Antioxidants & Redox Signaling 11, no. 10 (October 2009): 2505–16. https://doi.org/10.1089/ars.2009.2599.
Griffith B, Pendyala S, Hecker L, Lee PJ, Natarajan V, Thannickal VJ. NOX enzymes and pulmonary disease. Antioxidants & redox signaling. 2009 Oct;11(10):2505–16.
Griffith, Brian, et al. “NOX enzymes and pulmonary disease.Antioxidants & Redox Signaling, vol. 11, no. 10, Oct. 2009, pp. 2505–16. Epmc, doi:10.1089/ars.2009.2599.
Griffith B, Pendyala S, Hecker L, Lee PJ, Natarajan V, Thannickal VJ. NOX enzymes and pulmonary disease. Antioxidants & redox signaling. 2009 Oct;11(10):2505–2516.
Journal cover image

Published In

Antioxidants & redox signaling

DOI

EISSN

1557-7716

ISSN

1523-0864

Publication Date

October 2009

Volume

11

Issue

10

Start / End Page

2505 / 2516

Related Subject Headings

  • Respiratory System
  • Reperfusion Injury
  • Reactive Oxygen Species
  • NADPH Oxidases
  • Lung Neoplasms
  • Lung Diseases
  • Isoenzymes
  • Hypertension
  • Humans
  • Fibrosis