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Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank.

Publication ,  Journal Article
Chahal, D; Sharma, D; Keshavarzi, S; Arisar, FAQ; Patel, K; Xu, W; Bhat, M
Published in: Hepatol Int
April 2022

BACKGROUND: Lean NAFLD may differ from NAFLD found in overweight or obese patients. We used the UK biobank to conduct a cross-sectional study that examined features that distinguish lean NAFLD from overweight or obese NAFLD. METHODS: MRI-PDFF data were used to identify patients with NAFLD, with NAFLD defined as PDFF ≥ 5%. BMI patient cohorts were identified, with lean defined as a BMI < 25, and overweight or obese defined as a BMI ≥ 25. Variables of interest to fatty liver disease, including single nucleotide polymorphisms, were chosen from the UK biobank data portal. Logistic regression was used to generate models predictive of NAFLD in each cohort. RESULTS: 1007 patients had NAFLD, and of these, 871 had BMI ≥ 25, and 136 BMI < 25. Factors associated with NAFLD in patients with BMI < 25 included male sex, white blood cell count, red blood cell count, triglycerides, ALT, creatinine, visceral adipose tissue, rs58542926 T, and rs738409 G. In contrast, factors associated with NAFLD in patients with BMI ≥ 25 included male sex, waist circumference, HDL cholesterol, triglycerides, serum glucose, ALT, creatinine, urate, visceral adipose tissue, rs1260326 T, rs1044498 C, rs58542926 T, and rs738409 G. For lean patients, our generated prediction score had an AUC of 0.92, sensitivity of 0.90 and specificity of 0.81. For overweight or obese patients, the prediction score had an AUC of 0.86, sensitivity of 0.87 and specificity of 0.70. CONCLUSIONS: Our analysis suggests that lean and overweight or obese NAFLD are distinct entities. We have developed a risk score incorporating both clinical and genetic factors that accurately classify lean patients with NAFLD, with the potential to serve as a tool for screening purposes.

Duke Scholars

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Published In

Hepatol Int

DOI

EISSN

1936-0541

Publication Date

April 2022

Volume

16

Issue

2

Start / End Page

325 / 336

Location

United States

Related Subject Headings

  • United Kingdom
  • Triglycerides
  • Overweight
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Humans
  • Gastroenterology & Hepatology
  • Cross-Sectional Studies
  • Creatinine
 

Citation

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Chahal, D., Sharma, D., Keshavarzi, S., Arisar, F. A. Q., Patel, K., Xu, W., & Bhat, M. (2022). Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank. Hepatol Int, 16(2), 325–336. https://doi.org/10.1007/s12072-022-10304-z
Chahal, Daljeet, Divya Sharma, Sareh Keshavarzi, Fakhar Ali Qazi Arisar, Keyur Patel, Wei Xu, and Mamatha Bhat. “Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank.Hepatol Int 16, no. 2 (April 2022): 325–36. https://doi.org/10.1007/s12072-022-10304-z.
Chahal D, Sharma D, Keshavarzi S, Arisar FAQ, Patel K, Xu W, et al. Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank. Hepatol Int. 2022 Apr;16(2):325–36.
Chahal, Daljeet, et al. “Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank.Hepatol Int, vol. 16, no. 2, Apr. 2022, pp. 325–36. Pubmed, doi:10.1007/s12072-022-10304-z.
Chahal D, Sharma D, Keshavarzi S, Arisar FAQ, Patel K, Xu W, Bhat M. Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank. Hepatol Int. 2022 Apr;16(2):325–336.
Journal cover image

Published In

Hepatol Int

DOI

EISSN

1936-0541

Publication Date

April 2022

Volume

16

Issue

2

Start / End Page

325 / 336

Location

United States

Related Subject Headings

  • United Kingdom
  • Triglycerides
  • Overweight
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Humans
  • Gastroenterology & Hepatology
  • Cross-Sectional Studies
  • Creatinine