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In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain.

Publication ,  Journal Article
Wang, M; Feng, T; Jiang, H; Zhu, J; Feng, W; Chhatbar, PY; Zhang, J; Zhang, S
Published in: Front Hum Neurosci
2022

Cranial electrical stimulation (CES) has been applied at various current levels in both adults and children with neurological conditions with seemingly promising but somewhat inconsistent results. Stimulation-induced spatial electric fields (EFs) within a specific brain region are likely a significant contributing factor for the biological effects. Although several simulation models have been used to predict EF distributions in the brain, these models actually have not been validated by in vivo CES-induced EF measurements in the live human brain. This study directly measured the CES-induced voltage changes with implanted stereotactic-electroencephalographic (sEEG) electrodes in twenty-one epilepsy participants (16 adults and 5 children) and then compared these measured values with the simulated ones obtained from the personalized models. In addition, we further investigated the influence of stimulation frequency, intensity, electrode montage and age on EFs in parts of participants. We found both measured voltages and EFs obtained in vivo are highly correlated with the predicted ones in our cohort (Voltages: r = 0.93, p < 0.001; EFs: r = 0.73, p < 0.001). In white matter and gray matter, the measured voltages linearly increased when the stimulation intensity increased from 5 to 500 μA but showed no significant changes (averaged coefficient of variation <4.10%) with changing stimulation frequency from 0.5 to 200 Hz. Electrode montage, but not age, significantly affects the distribution of the EFs (n = 5, p < 0.01). Our in vivo measurements demonstrate that the individualized simulation model can reliably predict the CES-induced EFs in both adults and children. It also confirms that the CES-induced EFs highly depend on the electrode montages and individual anatomical features.

Duke Scholars

Published In

Front Hum Neurosci

DOI

ISSN

1662-5161

Publication Date

2022

Volume

16

Start / End Page

829745

Location

Switzerland

Related Subject Headings

  • Experimental Psychology
  • 5204 Cognitive and computational psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences
 

Citation

APA
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ICMJE
MLA
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Wang, M., Feng, T., Jiang, H., Zhu, J., Feng, W., Chhatbar, P. Y., … Zhang, S. (2022). In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain. Front Hum Neurosci, 16, 829745. https://doi.org/10.3389/fnhum.2022.829745
Wang, Minmin, Tao Feng, Hongjie Jiang, Junming Zhu, Wuwei Feng, Pratik Y. Chhatbar, Jianmin Zhang, and Shaomin Zhang. “In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain.Front Hum Neurosci 16 (2022): 829745. https://doi.org/10.3389/fnhum.2022.829745.
Wang M, Feng T, Jiang H, Zhu J, Feng W, Chhatbar PY, et al. In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain. Front Hum Neurosci. 2022;16:829745.
Wang, Minmin, et al. “In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain.Front Hum Neurosci, vol. 16, 2022, p. 829745. Pubmed, doi:10.3389/fnhum.2022.829745.
Wang M, Feng T, Jiang H, Zhu J, Feng W, Chhatbar PY, Zhang J, Zhang S. In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain. Front Hum Neurosci. 2022;16:829745.

Published In

Front Hum Neurosci

DOI

ISSN

1662-5161

Publication Date

2022

Volume

16

Start / End Page

829745

Location

Switzerland

Related Subject Headings

  • Experimental Psychology
  • 5204 Cognitive and computational psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences