Scholars@Duke publication: Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague.

Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague.

Publication , Journal Article

Wang, X; Li, P; Singh, AK; Zhang, X; Guan, Z; Curtiss, R; Sun, W

Published in: Proc Natl Acad Sci U S A

March 15, 2022

SignificanceYersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history. This plague bacillus has been used as a biological weapon during human history and is currently one of the deadliest biological threats. Currently, no licensed plague vaccines are available in the Western world. Since an array of immunogens are enclosed in outer membrane vesicles (OMVs), immune responses elicited by OMVs against a diverse range of antigens may reduce the likelihood of antigen circumvention. Therefore, self-adjuvanting OMVs from a remodeled Yersinia pseudotuberculosis strain as a type of plague vaccine could diversify prophylactic choices and solve current vaccine limitations.

Duke Scholars

Author Ziqiang Guan Biochemistry

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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.2109667119

EISSN

1091-6490

Publication Date

March 15, 2022

Volume

119

Issue

Start / End Page

e2109667119

Location

United States

Related Subject Headings

Yersinia pseudotuberculosis
Pore Forming Cytotoxic Proteins
Plasmids
Plague Vaccine
Plague
Mice
Lipid A
Lethal Dose 50
Antigens, Bacterial
Antibodies, Bacterial

Citation

APA

Chicago

ICMJE

MLA

NLM

Wang, X., Li, P., Singh, A. K., Zhang, X., Guan, Z., Curtiss, R., & Sun, W. (2022). Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague. Proc Natl Acad Sci U S A, 119(11), e2109667119. https://doi.org/10.1073/pnas.2109667119

Wang, Xiuran, Peng Li, Amit K. Singh, Xiangmin Zhang, Ziqiang Guan, Roy Curtiss, and Wei Sun. “Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague.” Proc Natl Acad Sci U S A 119, no. 11 (March 15, 2022): e2109667119. https://doi.org/10.1073/pnas.2109667119.

Wang X, Li P, Singh AK, Zhang X, Guan Z, Curtiss R, et al. Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2109667119.

Wang, Xiuran, et al. “Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague.” Proc Natl Acad Sci U S A, vol. 119, no. 11, Mar. 2022, p. e2109667119. Pubmed, doi:10.1073/pnas.2109667119.

Wang X, Li P, Singh AK, Zhang X, Guan Z, Curtiss R, Sun W. Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2109667119.