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An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.

Publication ,  Journal Article
Lin, H; Wang, M; Chen, Y; Nomura, K; Hui, S; Gui, J; Zhang, X; Wu, Y; Liu, J; Li, Q; Deng, Y; Li, L; Yuan, M; Wang, S; He, SY; He, Z
Published in: Science advances
March 2022

Global crop production is greatly reduced by vascular diseases. These diseases include bacterial blight of rice and crucifer black rot caused by Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas campestris pv. campestris (Xcc). The molecular mechanisms that activate vascular defense against such pathogens remains underexplored. Here, we show that an Arabidopsis MAPK phosphatase 1 (MKP1) mutant has increased host susceptibility to the adapted pathogen Xcc and is compromised in nonhost resistance to the rice pathogen Xoo. MKP1 regulates MAPK-mediated phosphorylation of the transcription factor MYB4 that negatively regulates vascular lignification through inhibiting lignin biosynthesis. Induction of lignin biosynthesis is, therefore, an important part of vascular-specific immunity. The role of MKP-MAPK-MYB signaling in lignin biosynthesis and vascular resistance to Xoo is conserved in rice, indicating that these factors form a tissue-specific defense regulatory network. Our study likely reveals a major vascular immune mechanism that underlies tissue-specific disease resistance against bacterial pathogens in plants.

Duke Scholars

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Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

March 2022

Volume

8

Issue

10

Start / End Page

eabg8723

Related Subject Headings

  • Xanthomonas
  • Repressor Proteins
  • Protein Tyrosine Phosphatases
  • Plant Diseases
  • Phosphorylation
  • Oryza
  • Lignin
  • Arabidopsis Proteins
  • Arabidopsis
 

Citation

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Lin, H., Wang, M., Chen, Y., Nomura, K., Hui, S., Gui, J., … He, Z. (2022). An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants. Science Advances, 8(10), eabg8723. https://doi.org/10.1126/sciadv.abg8723
Lin, Hui, Muyang Wang, Ying Chen, Kinya Nomura, Shugang Hui, Jinshan Gui, Xiawei Zhang, et al. “An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.Science Advances 8, no. 10 (March 2022): eabg8723. https://doi.org/10.1126/sciadv.abg8723.
Lin H, Wang M, Chen Y, Nomura K, Hui S, Gui J, et al. An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants. Science advances. 2022 Mar;8(10):eabg8723.
Lin, Hui, et al. “An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.Science Advances, vol. 8, no. 10, Mar. 2022, p. eabg8723. Epmc, doi:10.1126/sciadv.abg8723.
Lin H, Wang M, Chen Y, Nomura K, Hui S, Gui J, Zhang X, Wu Y, Liu J, Li Q, Deng Y, Li L, Yuan M, Wang S, He SY, He Z. An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants. Science advances. 2022 Mar;8(10):eabg8723.

Published In

Science advances

DOI

EISSN

2375-2548

ISSN

2375-2548

Publication Date

March 2022

Volume

8

Issue

10

Start / End Page

eabg8723

Related Subject Headings

  • Xanthomonas
  • Repressor Proteins
  • Protein Tyrosine Phosphatases
  • Plant Diseases
  • Phosphorylation
  • Oryza
  • Lignin
  • Arabidopsis Proteins
  • Arabidopsis