Antivenom Does Not Cause Snakebite Complications, Withholding It Does.
We read with interest the retrospective chart review "Crotalidae Polyvalent Immune Fab and Cost-Effective Management of Hospital Admission for Snakebites" by Bowden, et al. The efficacy of US snake antivenoms has been well established for decades. A randomized double-blind placebo-controlled clinical trial (RCT) has demonstrated Fab antivenom efficacy using patient-centered outcomes such as return of functionality and other patient-reported outcomes. These benefits occurred in a predominantly mildly envenomated patient population in a time-dependent manner. The cost-effectiveness of snake antivenom has been demonstrated globally, but no US cost-effectiveness studies have been published. Based on the evidence hierarchy of evidence-based medicine, the discordance between this study and the RCT merits discussion.
Duke Scholars
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- Surgery
- Snake Bites
- Retrospective Studies
- Humans
- Hospitalization
- Cost-Benefit Analysis
- Antivenins
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Surgery
- Snake Bites
- Retrospective Studies
- Humans
- Hospitalization
- Cost-Benefit Analysis
- Antivenins
- 3202 Clinical sciences
- 1103 Clinical Sciences