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Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis.

Publication ,  Journal Article
Muskens, IS; Feng, Q; Francis, SS; Walsh, KM; Mckean-Cowdin, R; Gauderman, WJ; de Smith, AJ; Wiemels, JL
Published in: Neurooncol Adv
2020

BACKGROUND: The incidence of pediatric brain tumors varies by race and ethnicity, but these relationships may be confounded by socioeconomic status (SES). In this study, the Surveillance, Epidemiology, and End Results Program (SEER) database was evaluated for associations between race/ethnicity and pediatric glioma and medulloblastoma risk with adjustment for SES. METHODS: Pediatric glioma and medulloblastoma cases from the SEER database (years: 2000-2016) were included. Differences in incidence rates by ethnicity, sex, age, and SES-related factors were evaluated by calculation of age-adjusted incidence rates (AAIRs) and annual percent change (APC). SES-related factors (percentage without less than high school graduation, median household income, and percentage foreign-born) were derived from the census at the county-level (year: 2000). Multivariable Poisson regression models with adjustment for selected covariates were constructed to evaluate risk factors. RESULTS: The highest AAIRs of pediatric glioma were observed among non-Hispanic Whites (AAIR: 2.91 per 100 000, 95%-CI: 2.84-2.99). An increasing incidence of pediatric glioma by calendar time was observed among non-Hispanic Whites and non-Hispanic Blacks (APC: 0.97%, 95%-CI: 0.28-1.68 and APC: 1.59%, 95%-CI: 0.03-3.18, respectively). Hispanic and non-Hispanic Black race/ethnicity was associated with lower risk when compared with non-Hispanic White (incidence rate ratios [IRRs]: 0.66, 95%-CI: 0.63-0.70; and 0.69, 95%-CI: 0.65-0.74, respectively). For medulloblastoma, the highest AAIR was observed for non-Hispanic Whites with a positive APC (1.52%, 95%-CI: 0.15-2.91). Hispanics and non-Hispanic Blacks had statistically significant lower IRRs compared with non-Hispanic Whites (IRRs: 0.83, 95%-CI: 0.73-0.94; and 0.72, 95%-CI: 0.59-0.87, respectively). CONCLUSION: Non-Hispanic White race/ethnicity was associated with higher pediatric glioma and medulloblastoma IRRs in models with adjustments for SES.

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Published In

Neurooncol Adv

DOI

EISSN

2632-2498

Publication Date

2020

Volume

2

Issue

1

Start / End Page

vdaa089

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Muskens, I. S., Feng, Q., Francis, S. S., Walsh, K. M., Mckean-Cowdin, R., Gauderman, W. J., … Wiemels, J. L. (2020). Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv, 2(1), vdaa089. https://doi.org/10.1093/noajnl/vdaa089
Muskens, Ivo S., Qianxi Feng, Stephen S. Francis, Kyle M. Walsh, Roberta Mckean-Cowdin, William J. Gauderman, Adam J. de Smith, and Joseph L. Wiemels. “Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis.Neurooncol Adv 2, no. 1 (2020): vdaa089. https://doi.org/10.1093/noajnl/vdaa089.
Muskens IS, Feng Q, Francis SS, Walsh KM, Mckean-Cowdin R, Gauderman WJ, et al. Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020;2(1):vdaa089.
Muskens, Ivo S., et al. “Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis.Neurooncol Adv, vol. 2, no. 1, 2020, p. vdaa089. Pubmed, doi:10.1093/noajnl/vdaa089.
Muskens IS, Feng Q, Francis SS, Walsh KM, Mckean-Cowdin R, Gauderman WJ, de Smith AJ, Wiemels JL. Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020;2(1):vdaa089.

Published In

Neurooncol Adv

DOI

EISSN

2632-2498

Publication Date

2020

Volume

2

Issue

1

Start / End Page

vdaa089

Location

England