Sex-Related Factors in Valvular Heart Disease: JACC Focus Seminar 5/7.
Numerous sex-based differences are observed across the spectrum of valvular heart disease, starting with pathophysiology and progression of disease, moving on to compensation and comorbidities (both cardiovascular such as coronary artery disease and noncardiovascular such as frailty), assessment of severity and hemodynamics including timing of intervention, and procedural risks/benefits and outcomes. The aortic valve is perhaps best understood with sex differences in both pathologic changes and response to volume and pressure overload, yet large gaps in our understanding still exist. Studies of other valve diseases have focused on differences in prevalence, presentation, and outcomes for surgical or transcatheter therapies. Defining sex-specific responses to valvular heart disease may improve disease recognition, define treatment strategies, and improve outcomes.
Duke Scholars
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- Sex Factors
- Male
- Humans
- Hemodynamics
- Heart Valve Prosthesis Implantation
- Heart Valve Diseases
- Female
- Cardiovascular System & Hematology
- Aortic Valve
- 3201 Cardiovascular medicine and haematology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sex Factors
- Male
- Humans
- Hemodynamics
- Heart Valve Prosthesis Implantation
- Heart Valve Diseases
- Female
- Cardiovascular System & Hematology
- Aortic Valve
- 3201 Cardiovascular medicine and haematology