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Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction.

Publication ,  Journal Article
Minhas, AMK; Bhopalwala, HM; Dewaswala, N; Salah, HM; Khan, MS; Shahid, I; Biegus, J; Lopes, RD; Pandey, A; Fudim, M
Published in: Curr Probl Cardiol
August 2023

Recent studies focusing on the prevalence, characteristics, and outcomes of primary heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) in non-alcoholic fatty liver disease (NAFLD) are sparse. We sought to assess these using a nationally-representative population. We used the 2016-2018 National Inpatient Sample database to study the prevalence, characteristics, clinical risk profiles, morbidity, mortality, cost, and resource utilization among primary HFpEF and HFrEF hospitalizations with and without NAFLD. In the period from January 1, 2016, to December 31, 2018, there were 3,522,459 admissions of patients aged ≥18 years with a diagnosis of primary HF. Of these, 82,585 (2.3%) hospitalizations had secondary diagnosis of NAFLD. Admissions with NAFLD and HFrEF were associated with higher rates of in-hospital mortality (aOR 1.84, CI 1.66-2.04, P < 0.001) compared to admissions of HFrEF without NAFLD. Similarly, hospitalizations with HFpEF-NAFLD were associated with higher rates of in hospital mortality (aOR 1.65 CI 1.43-1.9, P < 0.001) compared to HFpEF admissions without NAFLD. Pressors use, cardiogenic shock, AKI with or without dialysis use, cardiac arrest, LOS and hospitalization cost were higher in admissions of HFrEF and HFpEF with NAFLD compared to those without NAFLD. In-hospital mortality, was higher in primary HFrEF and HFpEF admissions with NAFLD compared to without NAFLD. Physicians must be aware of the worse clinical outcomes of HFrEF and HFpEF in patients with NAFLD. Further clinical research is needed to address the knowledge gap and treatment options available for the patients with HF and NAFLD.

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Published In

Curr Probl Cardiol

DOI

EISSN

1535-6280

Publication Date

August 2023

Volume

48

Issue

8

Start / End Page

101199

Location

Netherlands

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Non-alcoholic Fatty Liver Disease
  • Humans
  • Hospitals
  • Hospitalization
  • Heart Failure
  • Cardiovascular System & Hematology
  • Adult
  • Adolescent
 

Citation

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Minhas, A. M. K., Bhopalwala, H. M., Dewaswala, N., Salah, H. M., Khan, M. S., Shahid, I., … Fudim, M. (2023). Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction. Curr Probl Cardiol, 48(8), 101199. https://doi.org/10.1016/j.cpcardiol.2022.101199
Minhas, Abdul Mannan Khan, Huzefa M. Bhopalwala, Nakeya Dewaswala, Husam M. Salah, Muhammad Shahzeb Khan, Izza Shahid, Jan Biegus, Renato D. Lopes, Ambarish Pandey, and Marat Fudim. “Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction.Curr Probl Cardiol 48, no. 8 (August 2023): 101199. https://doi.org/10.1016/j.cpcardiol.2022.101199.
Minhas AMK, Bhopalwala HM, Dewaswala N, Salah HM, Khan MS, Shahid I, et al. Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction. Curr Probl Cardiol. 2023 Aug;48(8):101199.
Minhas, Abdul Mannan Khan, et al. “Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction.Curr Probl Cardiol, vol. 48, no. 8, Aug. 2023, p. 101199. Pubmed, doi:10.1016/j.cpcardiol.2022.101199.
Minhas AMK, Bhopalwala HM, Dewaswala N, Salah HM, Khan MS, Shahid I, Biegus J, Lopes RD, Pandey A, Fudim M. Association of Non-Alcoholic Fatty Liver Disease With in-Hospital Outcomes in Primary Heart Failure Hospitalizations With Reduced or Preserved Ejection Fraction. Curr Probl Cardiol. 2023 Aug;48(8):101199.
Journal cover image

Published In

Curr Probl Cardiol

DOI

EISSN

1535-6280

Publication Date

August 2023

Volume

48

Issue

8

Start / End Page

101199

Location

Netherlands

Related Subject Headings

  • Stroke Volume
  • Prognosis
  • Non-alcoholic Fatty Liver Disease
  • Humans
  • Hospitals
  • Hospitalization
  • Heart Failure
  • Cardiovascular System & Hematology
  • Adult
  • Adolescent