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Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV.

Publication ,  Journal Article
Overton, ET; Weir, IR; Zanni, MV; Fischinger, S; MacArthur, RD; Aberg, JA; Fitch, KV; Frank, M; Albrecht, H; Goodenough, E; Rhame, FS ...
Published in: J Acquir Immune Defic Syndr
August 1, 2022

BACKGROUND: Limited data are available regarding asymptomatic COVID-19 among people with HIV (PWH). Data on a representative subset of PWH enrolled in Randomized Trial to Prevent Vascular Events in HIV, a global clinical trial, are presented here. METHODS: Randomized Trial to Prevent Vascular Events in HIV is an atherosclerotic cardiovascular disease prevention trial among 7770 PWH on antiretroviral therapy. Beginning April 2020, targeted data on coronavirus disease 2019 (COVID-19) diagnosis and symptoms were collected during routine trial visits. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was defined as either COVID-19 clinical diagnosis or presence of SARS-CoV-2 Immunoglobulin G (IgG) or Immunoglobulin A (IgA) receptor binding domain protein (antispike) antibodies in the absence of prior COVID-19 vaccine. RESULTS: The group (N = 2464) had a median age 53 years, 35% female sex, 47% Black or African American race, median CD4 count 649 c/mm 3 , and 97% with HIV VL <400 cp/m. SARS-CoV-2 infection occurred in 318 persons (13%): 58 with clinical diagnosis and 260 with detectable antibodies. Of these PWH, 304 completed symptom questionnaires: 121 (40%) reported symptoms, but 183 (60%) were asymptomatic. PWH with asymptomatic SARS-CoV-2 infection were more likely to be from low-income or middle-income regions, of Black or African American race, older in age, and with higher atherosclerotic cardiovascular disease risk score. Symptomatic COVID was more common with obesity, metabolic syndrome, and low HDL levels. CD4 counts and HIV viral suppression rates were similar among PWH with symptomatic vs. asymptomatic COVID. CONCLUSIONS: Asymptomatic SARS-CoV-2 infection is common among antiretroviral therapy-treated PWH globally. We determined that 60% of infections in PWH were asymptomatic. HIV clinicians must remain vigilant about COVID-19 testing among PWH to identify asymptomatic cases.

Duke Scholars

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Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

August 1, 2022

Volume

90

Issue

4

Start / End Page

377 / 381

Location

United States

Related Subject Headings

  • Virology
  • SARS-CoV-2
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • Female
  • Cardiovascular Diseases
  • COVID-19 Vaccines
  • COVID-19 Testing
 

Citation

APA
Chicago
ICMJE
MLA
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Overton, E. T., Weir, I. R., Zanni, M. V., Fischinger, S., MacArthur, R. D., Aberg, J. A., … Grinspoon, S. K. (2022). Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV. J Acquir Immune Defic Syndr, 90(4), 377–381. https://doi.org/10.1097/QAI.0000000000003000
Overton, Edgar T., Isabelle R. Weir, Markella V. Zanni, Stephanie Fischinger, Rodger D. MacArthur, Judith A. Aberg, Kathleen V. Fitch, et al. “Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV.J Acquir Immune Defic Syndr 90, no. 4 (August 1, 2022): 377–81. https://doi.org/10.1097/QAI.0000000000003000.
Overton ET, Weir IR, Zanni MV, Fischinger S, MacArthur RD, Aberg JA, et al. Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV. J Acquir Immune Defic Syndr. 2022 Aug 1;90(4):377–81.
Overton, Edgar T., et al. “Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV.J Acquir Immune Defic Syndr, vol. 90, no. 4, Aug. 2022, pp. 377–81. Pubmed, doi:10.1097/QAI.0000000000003000.
Overton ET, Weir IR, Zanni MV, Fischinger S, MacArthur RD, Aberg JA, Fitch KV, Frank M, Albrecht H, Goodenough E, Rhame FS, Fichtenbaum CJ, Bloomfield GS, Malvestutto C, Supparatpinyo K, McCallum S, Douglas PS, Alter G, Ribaudo H, Grinspoon SK. Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV. J Acquir Immune Defic Syndr. 2022 Aug 1;90(4):377–381.

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

August 1, 2022

Volume

90

Issue

4

Start / End Page

377 / 381

Location

United States

Related Subject Headings

  • Virology
  • SARS-CoV-2
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • Female
  • Cardiovascular Diseases
  • COVID-19 Vaccines
  • COVID-19 Testing