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Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort.

Publication ,  Journal Article
Guniganti, R; Giordan, E; Chen, C-J; Abecassis, IJ; Levitt, MR; Durnford, A; Smith, J; Samaniego, EA; Derdeyn, CP; Kwasnicki, A; Alaraj, A ...
Published in: J Neurosurg
April 1, 2022

OBJECTIVE: Cranial dural arteriovenous fistulas (dAVFs) are rare lesions, hampering efforts to understand them and improve their care. To address this challenge, investigators with an established record of dAVF investigation formed an international, multicenter consortium aimed at better elucidating dAVF pathophysiology, imaging characteristics, natural history, and patient outcomes. This report describes the design of the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) and includes characterization of the 1077-patient cohort. METHODS: Potential collaborators with established interest in the field were identified via systematic review of the literature. To ensure uniformity of data collection, a quality control process was instituted. Data were retrospectively obtained. RESULTS: CONDOR comprises 14 centers in the United States, the United Kingdom, the Netherlands, and Japan that have pooled their data from 1077 dAVF patients seen between 1990 and 2017. The cohort includes 359 patients (33%) with Borden type I dAVFs, 175 (16%) with Borden type II fistulas, and 529 (49%) with Borden type III fistulas. Overall, 852 patients (79%) presented with fistula-related symptoms: 427 (40%) presented with nonaggressive symptoms such as tinnitus or orbital phenomena, 258 (24%) presented with intracranial hemorrhage, and 167 (16%) presented with nonhemorrhagic neurological deficits. A smaller proportion (224 patients, 21%), whose dAVFs were discovered incidentally, were asymptomatic. Many patients (85%, 911/1077) underwent treatment via endovascular embolization (55%, 587/1077), surgery (10%, 103/1077), radiosurgery (3%, 36/1077), or multimodal therapy (17%, 184/1077). The overall angiographic cure rate was 83% (758/911 treated), and treatment-related permanent neurological morbidity was 2% (27/1467 total procedures). The median time from diagnosis to follow-up was 380 days (IQR 120-1038.5 days). CONCLUSIONS: With more than 1000 patients, the CONDOR registry represents the largest registry of cranial dAVF patient data in the world. These unique, well-annotated data will enable multiple future analyses to be performed to better understand dAVFs and their management.

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Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

April 1, 2022

Volume

136

Issue

4

Start / End Page

951 / 961

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Humans
  • Embolization, Therapeutic
  • Cohort Studies
  • Central Nervous System Vascular Malformations
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

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Guniganti, R., Giordan, E., Chen, C.-J., Abecassis, I. J., Levitt, M. R., Durnford, A., … CONDOR Collaborators, . (2022). Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort. J Neurosurg, 136(4), 951–961. https://doi.org/10.3171/2021.1.JNS202790
Guniganti, Ridhima, Enrico Giordan, Ching-Jen Chen, Isaac Josh Abecassis, Michael R. Levitt, Andrew Durnford, Jessica Smith, et al. “Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort.J Neurosurg 136, no. 4 (April 1, 2022): 951–61. https://doi.org/10.3171/2021.1.JNS202790.
Guniganti R, Giordan E, Chen C-J, Abecassis IJ, Levitt MR, Durnford A, et al. Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort. J Neurosurg. 2022 Apr 1;136(4):951–61.
Guniganti, Ridhima, et al. “Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort.J Neurosurg, vol. 136, no. 4, Apr. 2022, pp. 951–61. Pubmed, doi:10.3171/2021.1.JNS202790.
Guniganti R, Giordan E, Chen C-J, Abecassis IJ, Levitt MR, Durnford A, Smith J, Samaniego EA, Derdeyn CP, Kwasnicki A, Alaraj A, Potgieser ARE, Sur S, Chen SH, Tada Y, Winkler E, Phelps RRL, Lai PMR, Du R, Abla A, Satomi J, Starke RM, van Dijk JMC, Amin-Hanjani S, Hayakawa M, Gross BA, Fox WC, Bulters D, Kim LJ, Sheehan J, Lanzino G, Piccirillo JF, Kansagra AP, Zipfel GJ, Consortium for Dural Arteriovenous Fistula Outcomes Research, CONDOR Collaborators. Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort. J Neurosurg. 2022 Apr 1;136(4):951–961.

Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

April 1, 2022

Volume

136

Issue

4

Start / End Page

951 / 961

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Humans
  • Embolization, Therapeutic
  • Cohort Studies
  • Central Nervous System Vascular Malformations
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences