Skip to main content

The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer.

Publication ,  Journal Article
Hiratsuka, Y; Kim, YJ; Suh, S-Y; Won, SH; Choi, SE; LeBlanc, TW; Kang, B; Lee, SW; Suh, KJ; Kim, J-W; Kim, SH; Kim, JW; Lee, K-W
Published in: Ann Palliat Med
July 2022

BACKGROUND: Several prognostic tools have been developed to aid clinicians in survival prediction. However, changes in symptoms are rarely included in established prognostic systems. We aimed to investigate the influence of changes in symptoms and quality of life (QOL) on survival time in outpatients with advanced cancer. METHODS: Study subjects included a subgroup of those with longitudinal symptom and QOL data within a larger, single-site parent study. We assessed patients' symptoms and QOL at enrollment and follow-up at an approximately 3-month interval. Patients' symptoms were evaluated by the Korean version of the Edmonton Symptom Assessment System (K-ESAS). QOL was checked by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Participants were categorized into three groups by changes in symptoms or QOL. These groups were: improved (having at least a one level of improvement in the response scale), stable (no change), or worsened (at least a one level of worsening in the scale). We compared survival time in the improved plus stable vs. worsened groups, using a log-rank test. RESULTS: We analyzed 60 patients, with a median survival time of 346 days. In the Worsened group, depression (P<0.01) and sleep disturbance (P<0.01) by K-ESAS, and dyspnea (P<0.03) per the EORTC QLQ-C30, were statistically significantly related to shorter survival time compared to 'improved and stable' group. There was no relationship between changes in other symptoms, overall QOL, and survival. CONCLUSIONS: Longitudinal assessment of depression, sleep disturbance and dyspnea may be useful in prognostication of patients with advanced cancer. Further studies are needed to confirm our findings with more consecutive assessments in diverse populations.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Palliat Med

DOI

EISSN

2224-5839

Publication Date

July 2022

Volume

11

Issue

7

Start / End Page

2338 / 2348

Location

China

Related Subject Headings

  • Surveys and Questionnaires
  • Quality of Life
  • Outpatients
  • Neoplasms
  • Humans
  • Dyspnea
  • 4203 Health services and systems
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hiratsuka, Y., Kim, Y. J., Suh, S.-Y., Won, S. H., Choi, S. E., LeBlanc, T. W., … Lee, K.-W. (2022). The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer. Ann Palliat Med, 11(7), 2338–2348. https://doi.org/10.21037/apm-22-33
Hiratsuka, Yusuke, Yu Jung Kim, Sang-Yeon Suh, Seon Hye Won, Sung Eun Choi, Thomas W. LeBlanc, Beodeul Kang, et al. “The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer.Ann Palliat Med 11, no. 7 (July 2022): 2338–48. https://doi.org/10.21037/apm-22-33.
Hiratsuka Y, Kim YJ, Suh S-Y, Won SH, Choi SE, LeBlanc TW, et al. The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer. Ann Palliat Med. 2022 Jul;11(7):2338–48.
Hiratsuka, Yusuke, et al. “The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer.Ann Palliat Med, vol. 11, no. 7, July 2022, pp. 2338–48. Pubmed, doi:10.21037/apm-22-33.
Hiratsuka Y, Kim YJ, Suh S-Y, Won SH, Choi SE, LeBlanc TW, Kang B, Lee SW, Suh KJ, Kim J-W, Kim SH, Kim JW, Lee K-W. The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer. Ann Palliat Med. 2022 Jul;11(7):2338–2348.

Published In

Ann Palliat Med

DOI

EISSN

2224-5839

Publication Date

July 2022

Volume

11

Issue

7

Start / End Page

2338 / 2348

Location

China

Related Subject Headings

  • Surveys and Questionnaires
  • Quality of Life
  • Outpatients
  • Neoplasms
  • Humans
  • Dyspnea
  • 4203 Health services and systems
  • 3202 Clinical sciences