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The role of astrocyte structural plasticity in regulating neural circuit function and behavior.

Publication ,  Journal Article
Lawal, O; Ulloa Severino, FP; Eroglu, C
Published in: Glia
August 2022

Brain circuits undergo substantial structural changes during development, driven by the formation, stabilization, and elimination of synapses. Synaptic connections continue to undergo experience-dependent structural rearrangements throughout life, which are postulated to underlie learning and memory. Astrocytes, a major glial cell type in the brain, are physically in contact with synaptic circuits through their structural ensheathment of synapses. Astrocytes strongly contribute to the remodeling of synaptic structures in healthy and diseased central nervous systems by regulating synaptic connectivity and behaviors. However, whether structural plasticity of astrocytes is involved in their critical functions at the synapse is unknown. This review will discuss the emerging evidence linking astrocytic structural plasticity to synaptic circuit remodeling and regulation of behaviors. Moreover, we will survey possible molecular and cellular mechanisms regulating the structural plasticity of astrocytes and their non-cell-autonomous effects on neuronal plasticity. Finally, we will discuss how astrocyte morphological changes in different physiological states and disease conditions contribute to neuronal circuit function and dysfunction.

Duke Scholars

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Published In

Glia

DOI

EISSN

1098-1136

Publication Date

August 2022

Volume

70

Issue

8

Start / End Page

1467 / 1483

Location

United States

Related Subject Headings

  • Synapses
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Brain
  • Astrocytes
  • 3209 Neurosciences
  • 1109 Neurosciences
 

Citation

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Lawal, O., Ulloa Severino, F. P., & Eroglu, C. (2022). The role of astrocyte structural plasticity in regulating neural circuit function and behavior. Glia, 70(8), 1467–1483. https://doi.org/10.1002/glia.24191
Lawal, Oluwadamilola, Francesco Paolo Ulloa Severino, and Cagla Eroglu. “The role of astrocyte structural plasticity in regulating neural circuit function and behavior.Glia 70, no. 8 (August 2022): 1467–83. https://doi.org/10.1002/glia.24191.
Lawal O, Ulloa Severino FP, Eroglu C. The role of astrocyte structural plasticity in regulating neural circuit function and behavior. Glia. 2022 Aug;70(8):1467–83.
Lawal, Oluwadamilola, et al. “The role of astrocyte structural plasticity in regulating neural circuit function and behavior.Glia, vol. 70, no. 8, Aug. 2022, pp. 1467–83. Pubmed, doi:10.1002/glia.24191.
Lawal O, Ulloa Severino FP, Eroglu C. The role of astrocyte structural plasticity in regulating neural circuit function and behavior. Glia. 2022 Aug;70(8):1467–1483.
Journal cover image

Published In

Glia

DOI

EISSN

1098-1136

Publication Date

August 2022

Volume

70

Issue

8

Start / End Page

1467 / 1483

Location

United States

Related Subject Headings

  • Synapses
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Brain
  • Astrocytes
  • 3209 Neurosciences
  • 1109 Neurosciences