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Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature.

Publication ,  Journal Article
Parakh, S; Maheshwari, S; Das, S; Kumar, V; Agrawal, R; Gupta, V; Mruthyunjaya, P; Luthra, S
Published in: Am J Ophthalmol Case Rep
September 2022

PURPOSE: To describe a case of presumed bilateral diffuse uveal melanocytic proliferation (BDUMP) associated with renal cell carcinoma (RCC) and provide an updated review of literature. OBSERVATIONS: A 58-year-old man, with a history of radical nephrectomy for RCC 8 years ago, presented with gradual diminution of vision. Based on multimodal imaging and detailed systemic evaluation, a diagnosis of presumed BDUMP and metastatic RCC was made. He was started on sunitinib malate as palliative chemotherapy. However, he refused plasmapheresis for BDUMP. The patient rapidly developed bilateral exudative retinal detachment. Subsequently, he progressed to bilateral neovascular glaucoma secondary to closed funnel retinal detachment. Eventually, he was lost to follow up after 13 months. CONCLUSIONS & IMPORTANCE: BDUMP portends an underlying advanced systemic malignancy. Studies have not conclusively proven any definite treatment for BDUMP and survival is generally poor. Ocular side effects of palliative targeted chemotherapy for the primary malignancy, such as sunitinib, should be borne in mind.

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Published In

Am J Ophthalmol Case Rep

DOI

EISSN

2451-9936

Publication Date

September 2022

Volume

27

Start / End Page

101582

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
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Parakh, S., Maheshwari, S., Das, S., Kumar, V., Agrawal, R., Gupta, V., … Luthra, S. (2022). Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature. Am J Ophthalmol Case Rep, 27, 101582. https://doi.org/10.1016/j.ajoc.2022.101582
Parakh, Shweta, Shrey Maheshwari, Shrutanjoy Das, Vinod Kumar, Rupesh Agrawal, Vishali Gupta, Prithvi Mruthyunjaya, and Saurabh Luthra. “Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature.Am J Ophthalmol Case Rep 27 (September 2022): 101582. https://doi.org/10.1016/j.ajoc.2022.101582.
Parakh S, Maheshwari S, Das S, Kumar V, Agrawal R, Gupta V, et al. Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature. Am J Ophthalmol Case Rep. 2022 Sep;27:101582.
Parakh, Shweta, et al. “Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature.Am J Ophthalmol Case Rep, vol. 27, Sept. 2022, p. 101582. Pubmed, doi:10.1016/j.ajoc.2022.101582.
Parakh S, Maheshwari S, Das S, Kumar V, Agrawal R, Gupta V, Mruthyunjaya P, Luthra S. Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature. Am J Ophthalmol Case Rep. 2022 Sep;27:101582.
Journal cover image

Published In

Am J Ophthalmol Case Rep

DOI

EISSN

2451-9936

Publication Date

September 2022

Volume

27

Start / End Page

101582

Location

United States