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Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review.

Publication ,  Journal Article
Clark, E; Faruque, S; Mutebi, C; Nagirimadugu, NV; Kim, A; Mahendran, M; Sullo, E; Morey, R; Turner, RW
Published in: J Neurol
September 2022

The objective of this systematic review is to synthesize the relevant literature published after 2016 to ascertain the current landscape of science that relates mild traumatic brain injury (mTBI) to the onset of Alzheimer's disease and related dementias (ADRD) and identify areas of need for future research. We conducted database searches and retrieved articles that were published after 2016 that utilized cognitive assessments to understand the relationship between mTBI and ADRD. We identified eight relevant articles in the review process, four of which presented a significant relationship between mTBI and disease or cognitive impairment outcomes. The studies included in this systematic review underscore the need for future research investigating a possible causal relationship between mTBI and ADRDs given the high prevalence of mTBI among brain injury patients and the lack of literature specifically addressing this issue. Future research should standardize the definitions of mTBI, AD, and ADRDs to create reliable and reproducible results that more comprehensively capture the nuances of this relationship.

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Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

September 2022

Volume

269

Issue

9

Start / End Page

4635 / 4645

Location

Germany

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Cognitive Dysfunction
  • Brain Injuries
  • Brain Concussion
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
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Clark, E., Faruque, S., Mutebi, C., Nagirimadugu, N. V., Kim, A., Mahendran, M., … Turner, R. W. (2022). Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review. J Neurol, 269(9), 4635–4645. https://doi.org/10.1007/s00415-022-11186-9
Clark, Emma, Saurab Faruque, Cedric Mutebi, Newton V. Nagirimadugu, Alyssa Kim, Malavika Mahendran, Elaine Sullo, Rajendra Morey, and Robert W. Turner. “Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review.J Neurol 269, no. 9 (September 2022): 4635–45. https://doi.org/10.1007/s00415-022-11186-9.
Clark E, Faruque S, Mutebi C, Nagirimadugu NV, Kim A, Mahendran M, et al. Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review. J Neurol. 2022 Sep;269(9):4635–45.
Clark, Emma, et al. “Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review.J Neurol, vol. 269, no. 9, Sept. 2022, pp. 4635–45. Pubmed, doi:10.1007/s00415-022-11186-9.
Clark E, Faruque S, Mutebi C, Nagirimadugu NV, Kim A, Mahendran M, Sullo E, Morey R, Turner RW. Investigating the relationship between mild traumatic brain injury and Alzheimer's disease and related dementias: a systematic review. J Neurol. 2022 Sep;269(9):4635–4645.
Journal cover image

Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

September 2022

Volume

269

Issue

9

Start / End Page

4635 / 4645

Location

Germany

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Cognitive Dysfunction
  • Brain Injuries
  • Brain Concussion
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences