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Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making.

Publication ,  Journal Article
LeBlanc, TW; Russell, NH; Hernandez-Aldama, L; Panter, C; Bell, TJ; Welch, V; Vega, DM; O'Hara, L; Stein, J; Barclay, M; Peloquin, F; Brown, A ...
Published in: Oncol Ther
December 2022

INTRODUCTION: Treatment decisions in older adults with acute myeloid leukemia (AML) are challenging, particularly for those who are not candidates for intensive chemotherapy (IC), and the trade-offs patients, their families and physicians consider when choosing a treatment option are not well understood. This qualitative research explored the value of extending survival and the treatment decision-making process from a multi-stakeholder perspective. METHODS: Overall, 28 patients with AML (≥ 65 years old, unsuitable for IC), 25 of their relatives and 10 independent physicians from the US, UK and Canada took part in one-on-one, 60-minute qualitative interviews. RESULTS: Across all stakeholders, improved health-related quality of life (HRQoL), extended survival and relief of AML symptoms were recognized as most important in AML treatment decision-making. However, extending survival in 'good health' was more important than extending survival alone, particularly because of the extra time it gives patients and their relatives together, and allows patients to achieve important goals. Patients' limited understanding of available treatment options, paired with incorrect perceptions of treatment side effects, impacted their involvement in the treatment decision-making process. Patients and physicians perceived physicians to have the most influence in the decision-making process despite their priorities not always aligning. CONCLUSION: These findings illustrate the importance of having structured discussions which explicitly assess patients' goals and their understanding and expectations of treatments and also the need for patient friendly resources about the lived experience of AML and available treatment options. These measures will help to ensure that patients are fully involved in the shared decision-making process.

Duke Scholars

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Published In

Oncol Ther

DOI

EISSN

2366-1089

Publication Date

December 2022

Volume

10

Issue

2

Start / End Page

421 / 440

Location

New Zealand

Related Subject Headings

  • 4206 Public health
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
LeBlanc, T. W., Russell, N. H., Hernandez-Aldama, L., Panter, C., Bell, T. J., Welch, V., … Walter, R. B. (2022). Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making. Oncol Ther, 10(2), 421–440. https://doi.org/10.1007/s40487-022-00200-9
LeBlanc, Thomas W., Nigel H. Russell, Loriana Hernandez-Aldama, Charlotte Panter, Timothy J. Bell, Verna Welch, Diana Merino Vega, et al. “Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making.Oncol Ther 10, no. 2 (December 2022): 421–40. https://doi.org/10.1007/s40487-022-00200-9.
LeBlanc TW, Russell NH, Hernandez-Aldama L, Panter C, Bell TJ, Welch V, et al. Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making. Oncol Ther. 2022 Dec;10(2):421–40.
LeBlanc, Thomas W., et al. “Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making.Oncol Ther, vol. 10, no. 2, Dec. 2022, pp. 421–40. Pubmed, doi:10.1007/s40487-022-00200-9.
LeBlanc TW, Russell NH, Hernandez-Aldama L, Panter C, Bell TJ, Welch V, Vega DM, O’Hara L, Stein J, Barclay M, Peloquin F, Brown A, Healy J, Morgan L, Gater A, Hohman R, Amer K, Maze D, Walter RB. Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making. Oncol Ther. 2022 Dec;10(2):421–440.

Published In

Oncol Ther

DOI

EISSN

2366-1089

Publication Date

December 2022

Volume

10

Issue

2

Start / End Page

421 / 440

Location

New Zealand

Related Subject Headings

  • 4206 Public health
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis