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Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group.

Publication ,  Journal Article
Flores, FX; Brophy, PD; Symons, JM; Fortenberry, JD; Chua, AN; Alexander, SR; Mahan, JD; Bunchman, TE; Blowey, D; Somers, MJG; Baum, M ...
Published in: Pediatr Nephrol
April 2008

Pediatric stem cell transplant (SCT) recipients commonly develop acute renal failure (ARF). We report the demographic and survival data of pediatric SCT patients enrolled in the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry. Since 1 January 2001, 51/370 (13.8%) patients entered in the ppCRRT Registry had received a SCT. Median age was 13.63 (0.53-23.52) years. The primary reasons for the initiation of continuous renal replacement therapy (CRRT) were treatment of fluid overload (FO) and electrolyte imbalance (49%), FO only (39%), electrolyte imbalance only (8%) and other reasons (4%). The CRRT modalities included continuous veno-veno hemodialysis (CVVHD), 43%, continuous veno-veno hemofiltration (CVVH), 37% and continuous veno-veno hemodiafiltration (CVVHDF), 20%. Seventy-six percent had multi-organ dysfunction syndrome (MODS), 72% received ventilatory support and the mean FO was 12.41 +/- 3.70%. Forty-five percent of patients survived. Patients receiving convective therapies had better survival rates (59% vs 27%, P < 0.05). Patients requiring ventilatory support had worse survival (35% vs 71%, P < 0.05). Mean airway pressure (Paw) at the end of CRRT was lower in survivors (8.7 +/- 2.94 vs 25.76 +/- 2.03 mmH(2)O, P < 0.05). Development of high mean airway pressure in non-survivors is likely related to non-fluid injury, as it was not prevented by early and aggressive fluid management by CRRT therapy.

Duke Scholars

Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

April 2008

Volume

23

Issue

4

Start / End Page

625 / 630

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Survival Rate
  • Stem Cell Transplantation
  • Renal Replacement Therapy
  • Renal Dialysis
  • Registries
  • Prospective Studies
  • Postoperative Complications
  • Male
 

Citation

APA
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ICMJE
MLA
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Flores, F. X., Brophy, P. D., Symons, J. M., Fortenberry, J. D., Chua, A. N., Alexander, S. R., … Goldstein, S. L. (2008). Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group. Pediatr Nephrol, 23(4), 625–630. https://doi.org/10.1007/s00467-007-0672-2
Flores, Francisco X., Patrick D. Brophy, Jordan M. Symons, James D. Fortenberry, Annabelle N. Chua, Steven R. Alexander, John D. Mahan, et al. “Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group.Pediatr Nephrol 23, no. 4 (April 2008): 625–30. https://doi.org/10.1007/s00467-007-0672-2.
Flores FX, Brophy PD, Symons JM, Fortenberry JD, Chua AN, Alexander SR, et al. Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group. Pediatr Nephrol. 2008 Apr;23(4):625–30.
Flores, Francisco X., et al. “Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group.Pediatr Nephrol, vol. 23, no. 4, Apr. 2008, pp. 625–30. Pubmed, doi:10.1007/s00467-007-0672-2.
Flores FX, Brophy PD, Symons JM, Fortenberry JD, Chua AN, Alexander SR, Mahan JD, Bunchman TE, Blowey D, Somers MJG, Baum M, Hackbarth R, Chand D, McBryde K, Benfield M, Goldstein SL. Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group. Pediatr Nephrol. 2008 Apr;23(4):625–630.
Journal cover image

Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

April 2008

Volume

23

Issue

4

Start / End Page

625 / 630

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Survival Rate
  • Stem Cell Transplantation
  • Renal Replacement Therapy
  • Renal Dialysis
  • Registries
  • Prospective Studies
  • Postoperative Complications
  • Male