Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.
Publication
, Journal Article
Anwar, IJ; DeLaura, IF; Gao, Q; Ladowski, J; Jackson, AM; Kwun, J; Knechtle, SJ
Published in: Front Immunol
2022
Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical impact of sensitization and ABMR, the B cell response under current immunosuppressive regimens, and ongoing clinical trials for ABMR and desensitization treatment.
Duke Scholars
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Published In
Front Immunol
DOI
EISSN
1664-3224
Publication Date
2022
Volume
13
Start / End Page
903068
Location
Switzerland
Related Subject Headings
- Kidney Transplantation
- Isoantibodies
- Immunosuppressive Agents
- Graft Survival
- Graft Rejection
- 3204 Immunology
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 1108 Medical Microbiology
- 1107 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Anwar, I. J., DeLaura, I. F., Gao, Q., Ladowski, J., Jackson, A. M., Kwun, J., & Knechtle, S. J. (2022). Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions. Front Immunol, 13, 903068. https://doi.org/10.3389/fimmu.2022.903068
Anwar, Imran J., Isabel F. DeLaura, Qimeng Gao, Joseph Ladowski, Annette M. Jackson, Jean Kwun, and Stuart J. Knechtle. “Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.” Front Immunol 13 (2022): 903068. https://doi.org/10.3389/fimmu.2022.903068.
Anwar IJ, DeLaura IF, Gao Q, Ladowski J, Jackson AM, Kwun J, et al. Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions. Front Immunol. 2022;13:903068.
Anwar, Imran J., et al. “Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.” Front Immunol, vol. 13, 2022, p. 903068. Pubmed, doi:10.3389/fimmu.2022.903068.
Anwar IJ, DeLaura IF, Gao Q, Ladowski J, Jackson AM, Kwun J, Knechtle SJ. Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions. Front Immunol. 2022;13:903068.
Published In
Front Immunol
DOI
EISSN
1664-3224
Publication Date
2022
Volume
13
Start / End Page
903068
Location
Switzerland
Related Subject Headings
- Kidney Transplantation
- Isoantibodies
- Immunosuppressive Agents
- Graft Survival
- Graft Rejection
- 3204 Immunology
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 1108 Medical Microbiology
- 1107 Immunology