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Family matters: How MYC family oncogenes impact small cell lung cancer.

Publication ,  Journal Article
Brägelmann, J; Böhm, S; Guthrie, MR; Mollaoglu, G; Oliver, TG; Sos, ML
Published in: Cell Cycle
August 18, 2017

Small cell lung cancer (SCLC) is one of the most deadly cancers and currently lacks effective targeted treatment options. Recent advances in the molecular characterization of SCLC has provided novel insight into the biology of this disease and raises hope for a paradigm shift in the treatment of SCLC. We and others have identified activation of MYC as a driver of susceptibility to Aurora kinase inhibition in SCLC cells and tumors that translates into a therapeutic option for the targeted treatment of MYC-driven SCLC. While MYC shares major features with its paralogs MYCN and MYCL, the sensitivity to Aurora kinase inhibitors is unique for MYC-driven SCLC. In this review, we will compare the distinct molecular features of the 3 MYC family members and address the potential implications for targeted therapy of SCLC.

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Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

August 18, 2017

Volume

16

Issue

16

Start / End Page

1489 / 1498

Location

United States

Related Subject Headings

  • Small Cell Lung Carcinoma
  • Signal Transduction
  • Proto-Oncogene Proteins c-myc
  • Oncogenes
  • Lung Neoplasms
  • Humans
  • Disease Models, Animal
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology
 

Citation

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Brägelmann, J., Böhm, S., Guthrie, M. R., Mollaoglu, G., Oliver, T. G., & Sos, M. L. (2017). Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle, 16(16), 1489–1498. https://doi.org/10.1080/15384101.2017.1339849
Brägelmann, Johannes, Stefanie Böhm, Matthew R. Guthrie, Gurkan Mollaoglu, Trudy G. Oliver, and Martin L. Sos. “Family matters: How MYC family oncogenes impact small cell lung cancer.Cell Cycle 16, no. 16 (August 18, 2017): 1489–98. https://doi.org/10.1080/15384101.2017.1339849.
Brägelmann J, Böhm S, Guthrie MR, Mollaoglu G, Oliver TG, Sos ML. Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle. 2017 Aug 18;16(16):1489–98.
Brägelmann, Johannes, et al. “Family matters: How MYC family oncogenes impact small cell lung cancer.Cell Cycle, vol. 16, no. 16, Aug. 2017, pp. 1489–98. Pubmed, doi:10.1080/15384101.2017.1339849.
Brägelmann J, Böhm S, Guthrie MR, Mollaoglu G, Oliver TG, Sos ML. Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle. 2017 Aug 18;16(16):1489–1498.

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

August 18, 2017

Volume

16

Issue

16

Start / End Page

1489 / 1498

Location

United States

Related Subject Headings

  • Small Cell Lung Carcinoma
  • Signal Transduction
  • Proto-Oncogene Proteins c-myc
  • Oncogenes
  • Lung Neoplasms
  • Humans
  • Disease Models, Animal
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology