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Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study.

Publication ,  Journal Article
Jung, J-Y; Yoon, D-K; Barraclough, B; Lee, HC; Suh, TS; Lu, B
Published in: Oncotarget
June 13, 2017

The aim of this study is to compare between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT) and to analyze dose escalation using a Monte Carlo simulation. We simulated a proton beam passing through the water with a boron uptake region (BUR) in MCNPX. To estimate the interaction between neutrons/protons and borons by the alpha particle, the simulation yielded with a variation of the center of the BUR location and proton energies. The variation and influence about the alpha particle were observed from the percent depth dose (PDD) and cross-plane dose profile of both the neutron and proton beams. The peak value of the maximum dose level when the boron particle was accurately labeled at the region was 192.4% among the energies. In all, we confirmed that prompt gamma rays of 478 keV and 719 keV were generated by the nuclear reactions in PBFT and BNCT, respectively. We validated the dramatic effectiveness of the alpha particle, especially in PBFT. The utility of PBFT was verified using the simulation and it has a potential for application in radiotherapy.

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 13, 2017

Volume

8

Issue

24

Start / End Page

39774 / 39781

Location

United States

Related Subject Headings

  • Radiotherapy Dosage
  • Protons
  • Phantoms, Imaging
  • Monte Carlo Method
  • Humans
  • Computer Simulation
  • Boron Neutron Capture Therapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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ICMJE
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Jung, J.-Y., Yoon, D.-K., Barraclough, B., Lee, H. C., Suh, T. S., & Lu, B. (2017). Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study. Oncotarget, 8(24), 39774–39781. https://doi.org/10.18632/oncotarget.15700
Jung, Joo-Young, Do-Kun Yoon, Brendan Barraclough, Heui Chang Lee, Tae Suk Suh, and Bo Lu. “Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study.Oncotarget 8, no. 24 (June 13, 2017): 39774–81. https://doi.org/10.18632/oncotarget.15700.
Jung J-Y, Yoon D-K, Barraclough B, Lee HC, Suh TS, Lu B. Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study. Oncotarget. 2017 Jun 13;8(24):39774–81.
Jung, Joo-Young, et al. “Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study.Oncotarget, vol. 8, no. 24, June 2017, pp. 39774–81. Pubmed, doi:10.18632/oncotarget.15700.
Jung J-Y, Yoon D-K, Barraclough B, Lee HC, Suh TS, Lu B. Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a monte carlo study. Oncotarget. 2017 Jun 13;8(24):39774–39781.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 13, 2017

Volume

8

Issue

24

Start / End Page

39774 / 39781

Location

United States

Related Subject Headings

  • Radiotherapy Dosage
  • Protons
  • Phantoms, Imaging
  • Monte Carlo Method
  • Humans
  • Computer Simulation
  • Boron Neutron Capture Therapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis