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Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy.

Publication ,  Journal Article
Rose, JE; Behm, FM; Botts, TL; Botts, DR; Willette, PN; Vocci, F; McCarty, J
Published in: Psychopharmacology (Berl)
September 2022

RATIONALE: Current nicotine replacement products provide a much slower onset of nicotine delivery than cigarettes, and hence are only marginally effective at supplanting cigarette smoking. Therefore, more effective forms of nicotine replacement are needed. OBJECTIVES: This initial investigation characterized the pharmacokinetic (PK) and subjective effects of a novel sublingual (SL) nicotine tablet designed to deliver nicotine more rapidly to the bloodstream of smokers. METHODS: Study 1 (N = 6) characterized the pharmacokinetics of a 2 mg nicotine SL tablet in comparison to an FDA-approved, marketed 2 mg nicotine lozenge. Study 2 (N = 24) assessed subjective responses of smokers to a single use of a 1 mg and 2 mg SL tablet. RESULTS: Study 1 found that the time to maximum blood nicotine concentrations was significantly shorter for the SL tablet (14 min) than for the lozenge (82 min), and the initial rate of nicotine absorption was higher (0.4 ng/mL*min vs. 0.0 ng/mL*min), supporting the hypothesis that the SL tablet delivered nicotine more rapidly. Study 2 found that participants reported immediate relief of nicotine withdrawal symptoms after tablet administration, and craving reduction after the 2 mg tablet approached the degree reported for their usual brands of cigarettes (4.2 vs. 4.6 on a 7-point scale). Other subjective responses showed the tablet to be an appealing alternative to smoking. CONCLUSIONS: The novel SL tablet studied shows promise as a nicotine substitution strategy for tobacco harm reduction and smoking cessation treatment. Additional studies are warranted to further investigate the potential of this new approach.

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Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2022

Volume

239

Issue

9

Start / End Page

2853 / 2862

Location

Germany

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Tobacco Products
  • Tablets
  • Smoking Cessation
  • Psychiatry
  • Nicotine
  • Nicotiana
  • Humans
  • Electronic Nicotine Delivery Systems
  • 5202 Biological psychology
 

Citation

APA
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ICMJE
MLA
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Rose, J. E., Behm, F. M., Botts, T. L., Botts, D. R., Willette, P. N., Vocci, F., & McCarty, J. (2022). Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy. Psychopharmacology (Berl), 239(9), 2853–2862. https://doi.org/10.1007/s00213-022-06171-z
Rose, Jed E., Frederique M. Behm, Tanaia L. Botts, David R. Botts, Perry N. Willette, Frank Vocci, and John McCarty. “Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy.Psychopharmacology (Berl) 239, no. 9 (September 2022): 2853–62. https://doi.org/10.1007/s00213-022-06171-z.
Rose JE, Behm FM, Botts TL, Botts DR, Willette PN, Vocci F, et al. Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy. Psychopharmacology (Berl). 2022 Sep;239(9):2853–62.
Rose, Jed E., et al. “Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy.Psychopharmacology (Berl), vol. 239, no. 9, Sept. 2022, pp. 2853–62. Pubmed, doi:10.1007/s00213-022-06171-z.
Rose JE, Behm FM, Botts TL, Botts DR, Willette PN, Vocci F, McCarty J. Novel rapid-acting sublingual nicotine tablet as a cigarette substitution strategy. Psychopharmacology (Berl). 2022 Sep;239(9):2853–2862.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2022

Volume

239

Issue

9

Start / End Page

2853 / 2862

Location

Germany

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Tobacco Products
  • Tablets
  • Smoking Cessation
  • Psychiatry
  • Nicotine
  • Nicotiana
  • Humans
  • Electronic Nicotine Delivery Systems
  • 5202 Biological psychology